Transition metal-free direct amination of benzoxazoles using formamides as nitrogen sources

A transition metal-free method for the direct amination of benzoxazoles using formamides as nitrogen sources is reported, which was mediated by an inexpensive and environmentally friendly tetrabutylammonium iodide/tea-butyl hydroperoxide system and gave the 2-aminobenzoxazole derivatives with moderate to good yields. (C) 2014 Elsevier Ltd. All rights reserved.