Chemoselective aerobic oxidation catalyzed by a metal/stable organoradical redox conjugate

This review summarizes recent advances of catalytic chemoselective aerobic oxidations promoted by a metal/stable organoradical redox conjugate. The sophisticated system exhibits high activity and chemoselectivity and is recently applied to late-stage transformations for complex natural product synthesis and a polypeptide transformation. The characteristics of the catalytic system are likely due to the unique mechanism ([1e + 1e] oxidation), which takes intrinsic advantages of cooperative work of first-row transition metals and stable organoradicals (radical-conjugated redox catalysis). (C) 2014 Published by Elsevier Ltd.