期刊
TETRAHEDRON LETTERS
卷 55, 期 23, 页码 3440-3442出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.04.077
关键词
Organocatalysis; Condensation reactions; Deep eutectic; Carbolines
Deep eutectic solvents (such as the combination of either urea or glycerol with choline chloride) are effective solvents/organocatalysts for Pictet-Spengler condensations to form carbolines. The reaction conditions are quite mild and do not require additional Bronsted or Lewis acid catalyst. Given the inexpensive, non-toxic, and recyclable nature of the DES, these reaction conditions are simple and highly environmentally friendly. (C) 2014 Elsevier Ltd. All rights reserved.
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