Article
Polymer Science
Benjamin M. Alameda, Joseph Scott Murphy, Bernardo L. Barea-Lopez, Karly D. Knox, Jonathan D. Sisemore, Derek L. Patton
Summary: Hydrolytically degradable poly(beta-thioether ester ketal) thermosets were synthesized by radical-mediated thiol-ene photopolymerization using different ketal structures and pH values as tunable factors. Complete degradation was observed under acidic, neutral pH, and high humidity conditions, showing tunable degradation rates.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Yu Zhao, Zitong Zhou, Lvling Liu, Man Chen, Weiguang Yang, Qi Chen, Michael G. Gardiner, Martin G. Banwell
Summary: An operationally simple synthesis of Z-configured and C3-unsubstituted N-sulfonyl-2-iminocoumarins can be achieved by reacting 2-(1-hydroxyprop-2-yn-1-yl)phenols with sulfonyl azides. The cascade process likely starts with a copper-catalyzed alkyne-azide cycloaddition reaction, leading to the formation of the desired product.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Maria Galiana-Cameo, Vincenzo Passarelli, Jesus J. Perez-Torrente, Andrea Di Giuseppe, Ricardo Castarlenas
Summary: A series of rhodium complexes, both neutral and cationic, have been reported with different synthetic pathways for catalytic reactions, exhibiting varying activities in the phenylacetylene-methanol transformations.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Zunkai Xu, Tao Liu, Yaoyao Jiang, Zhixia Chen, Xiaoguang Shi, Yang Xu, Na Yu, Xia Hua, Xing-Jie Liang, Xiaoyong Yuan, Shutao Guo
Summary: Injectable long-acting prodrug-based microcrystals with an acid-sensitive ketal linker were synthesized for developing extended-release antipsychotic drugs. The drug exposure was prolonged in rats treated with the prodrug-based microcrystals, and the release rate decreased with increasing microcrystal size. Moreover, the drug release from the microcrystals was considerably decreased in an inflammation model, indicating an immune-mediated boost in release post-injection.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Jasnoor S. Mann, Binh Khanh Mai, Thanh Vinh Nguyen
Summary: The carbonyl-alkyne metathesis (CAM) reaction is a versatile method to access alpha,beta-unsaturated carbonyl compounds, which are important precursors and structural motifs in biologically active substances. We developed an efficient organic Lewis acid catalytic system that promotes both intramolecular and intermolecular CAM reactions. Our metal-free protocol can produce a diverse family of useful organic structures from a broad range of substrates.
Article
Chemistry, Physical
Yeong Bum Kim, Dongwook Kim, Shashikant U. Dighe, Sukbok Chang, Jung-Woo Park
Summary: This research describes a novel cobalt-catalyzed reaction for the synthesis of terminal branched allylsilanes under mild conditions. Mechanistic studies show the key intermediate and the order of bond migration involved in the process.
Article
Chemistry, Medicinal
Huaran Zhang, Shuqi Wang, Qingying Liu, Hao Zheng, Xiaoqing Liu, Xiaoning Wang, Tao Shen, Dongmei Ren
Summary: Eight new lignans, named dracomolphin A-E, and eight known lignans were isolated from the aerial part of Dracocephalum moldavica. Dracomolphin A was elucidated as a mixture of two diastereomeric pairs of enantiomers, all successfully separated by chiral HPLC. Some compounds showed potential Nrf2 transcriptional activation and antilung cancer cell activity.
Article
Multidisciplinary Sciences
Na Yu, Yang Xu, Tao Liu, Haiping Zhong, Zunkai Xu, Tianjiao Ji, Hui Zou, Jingqing Mu, Ziqi Chen, Xing-Jie Liang, Linqi Shi, Daniel S. Kohane, Shutao Guo
Summary: The authors have developed an organocatalytic transisopropenylation approach for the synthesis of isopropenyl ethers with mild reaction conditions and a wide range of substrates, enabling the preparation of acid-sensitive ketal-linked prodrugs and biomaterials.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Dilip K. Pandey, Eugene Khaskin, Shrinwantu Pal, Robert R. Fayzullin, Julia R. Khusnutdinova
Summary: We describe an efficient semihydrogenation of terminal alkynes using a modified tetramethylated PNP pincer Fe hydride complex. The modified complex shows different reactivity compared to a classical PNP Fe hydride complex with CH2 arms, which predominantly catalyzes terminal alkyne dimerization even in the presence of H-2. The modified PNP ligand allows for selective alkene formation, eliminating dimerization side products and minimizing overreduction.
Review
Chemistry, Multidisciplinary
Scott R. Docherty, Christophe Coperet
Summary: This article describes efforts to understand complex materials capable of selective thermochemical conversion of CO2 to methanol using a surface organometallic chemistry approach. It focuses on the roles of metal-metal synergy and metal-support interfaces in determining the reactivity of various systems for the conversion of CO2 to methanol.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Hongyu Guo, Sheng Zhang, Yang Li, Xiaoqiang Yu, Xiujuan Feng, Yoshinori Yamamoto, Ming Bao
Summary: A palladium-catalyzed tail-to-tail reductive dimerization reaction of terminal alkynes is reported for the first time, leading to the efficient transformation of aromatic and aliphatic alkynes into 2,3-dibranched butadienes. The control of reaction solution acidity, achieved by a combination of pivalic acid and para-toluenesulfonic acid, is crucial for the selective tail-to-tail reductive dimerization reaction, which is proposed to proceed via a cationic alkenyl palladium intermediate under acidic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Organic
Muriel Amatore, Jean-Luc Parrain, Laurent Commeiras
Summary: Alkyne surrogates have emerged as alternative substitution partners in organic synthesis, overcoming drawbacks associated with alkynes and offering new opportunities for the preparation of high value molecules.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Jin-Feng Lv, Yu-Fang Tan, Ya-Nan Zhao, Dan Yang, Yan-Hong He, Zhi Guan
Summary: The paper describes an electrochemical method for the synthesis of N-vinyl benzotriazoles by coupling olefins with benzotriazoles to form C(sp(2))-N bonds. It is a highly atom-economic and clean reaction, with nBu4NI serving as both an electrolyte and an iodine mediator, and hydrogen as the only byproduct.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhaoyang Cheng, Minghua Li, Xu-Yang Zhang, Yue Sun, Qing-Lei Yu, Xing-Hong Zhang, Zhan Lu
Summary: A cobalt-catalyzed regiodivergent double hydrosilylation reaction has been developed, enabling the synthesis of bis(silane)s with specific regioselectivity. These bis(silane)s show promising applications in optical materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Borja Cirera, Alexander Riss, Pingo Mutombo, Jose Urgel, Jose Santos, Marco Di Giovannantonio, Roland Widmer, Samuel Stolz, Qiang Sun, Max Bommert, Roman Fasel, Pavel Jelinek, Willi Auwarter, Nazario Martin, David Ecija
Summary: The design of organometallic complexes is crucial in modern organic chemistry and catalysis. On-surface synthesis has recently emerged as a disruptive method to design compounds and nanomaterials previously considered impossible. The activation of inner diacetylene moieties of a molecular precursor by copper surface adatoms has led to the formation of unprecedented organocopper metallacycles on Cu(111), paving the way for new avenues in organometallic compound engineering and polyyne chemistry on surfaces.
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
