期刊
TETRAHEDRON LETTERS
卷 54, 期 36, 页码 4922-4925出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.07.005
关键词
Oxidative amidation; Benzyl alcohol; Amides; Iron(III) nitrate; Tandem oxidation
资金
- GlaxoSmithKline (GSK)
- Singapore Economic Development Board (EDB) for Green and Sustainable Manufacturing (GSM)
- Agency for Science, Technology and Research (A*STAR), Singapore
A tandem process for the oxidative amidation of benzyl alcohols with amine hydrochloride salts has been developed using inexpensive Fe(NO3)(3) as the catalyst, air and aqueous t-butyl hydroperoxide as oxidants. A wide range of benzamides have been synthesized under mild conditions. This greener amide formation method provides an economical and practical assess to benzamides from readily available and inexpensive starting materials. (C) 2013 Elsevier Ltd. All rights reserved.
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