A robust Ru-PNNP catalyst system for the asymmetric hydrogenation of α,β-unsaturated ketones to allylic alcohol

A robust and stable Ru-Biphosphinobioxazoline catalyst system is discovered for the highly enantioselective hydrogenation of enones to allylic alcohols. A series of acyclic alpha,beta-unsaturated ketones react well affording the desired products in high yields (up to 98%) and enantioselectivities (up to 98% ee). Simple manipulation process and tolerance of water and air make this catalysis more practical and appealing. (C) 2013 Elsevier Ltd. All rights reserved.