期刊
TETRAHEDRON LETTERS
卷 54, 期 21, 页码 2619-2622出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.03.019
关键词
Atom transfer radical cyclization; Azaspirodecanes; Copper; Dearomatization; Heterocycles
资金
- Spanish Ministry of Economy and Competitiveness [CTQ2010-14846/BQU]
An atom transfer radical dearomatizing spirocyclization from N-benzyltrichloroacetamides using CuCl regioselectively leads to 2-azaspiro[4.5]decadienes, in which the labile allylic chlorine atom is easily replaced by a hydroxyl group in aqueous medium or by quenching with methanol or allylamine. After oxidation of the target compound, the N-tert-butyl group can be removed from the resulting spirocyclohexanedienone. (c) 2013 Elsevier Ltd. All rights reserved.
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