Article
Chemistry, Physical
Xinyue Sun, Yuan Li, Haiyang Yu, Xiaoning Jin, Xiaofei Ma, Yue Cheng, Yuping Wei, Yong Wang
Summary: Six inclusion complexes based on sulfobutyl-beta-cyclodextrin and lycorine hydrochloride were prepared and characterized. The complexes showed excellent encapsulation effect, likely due to the electrostatic interaction between the sulfonic group of sulfobutyl-beta-cyclodextrin and the quaternary amino group of lycorine hydrochloride. Furthermore, the complexes exhibited pH-sensitive drug release, good solubility, stability, and blood compatibility, suggesting their potential as suitable drug carriers.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Organic
Siqi Dong, Shaofeng Xu, Yashi Zou, Zhaodi Li, Kai Xu, Daxu Fu, Delong Liu, Wanbin Zhang
Summary: A RuPHOX/Pd catalyzed asymmetric allylic substitution cascade of α-carbonylamides with an allylic meso-dicarbonate has been developed to synthesize chiral 3-acyl bicyclolactams bearing three vicinal carbon stereocenters in high yields. The products exhibited excellent enantioselectivity with up to 99% ee and high diastereoselectivity with >20:1 dr. Mechanistic studies revealed a dynamic kinetic resolution process during the second step of the cascade reaction, which contributed to the high diastereoselectivity. The protocol can be scaled up and the resulting products are versatile for further transformations, especially in the synthesis of natural products.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Plant Sciences
Zheng Wang, Ying Chen, Mingming Gu, Zhen Wu, Baoping Ding, Wenwen Yang, Xue Wu, Changyu Wang, Xuhui Gao, Yang Yang, Guilin Yin
Summary: This study found that lycorine (LYC) has a protective effect against doxorubicin (ADR)-induced cardiotoxicity and exerts its effects through the SIRT1/PPAR gamma signaling pathway. The results provide a theoretical basis for the development of LYC as a potential cardioprotective drug.
Review
Pharmacology & Pharmacy
Chee Kei Kong, Liang Ee Low, Wei Sheng Siew, Wei-Hsum Yap, Kooi-Yeong Khaw, Long Chiau Ming, Andrei Mocan, Bey-Hing Goh, Poh Hui Goh
Summary: Snowdrop, an iconic early spring flowering plant of the genus Galanthus (Amaryllidaceae), is economically important as an ornament and has gained scientific and commercial interest due to the discovery of Galanthamine as a treatment for Alzheimer's disease. This review discusses the bioactivities of Galanthus spp including anticholinesterase, antimicrobial, antioxidant, and anticancer potential, highlighting their potential for drug discovery and nutraceutical development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shuangshuang Yin, Shenshen Yang, Yanming Luo, Jia Lu, Gaoyong Hu, Kailong Wang, Yingying Shao, Shiyue Zhou, Sangho Koo, Yuling Qiu, Tao Wang, Haiyang Yu
Summary: The study identifies CDK1, CCNB1, and CCNB2 as potential diagnostic and prognostic biomarkers for HCC, with CDK1 being a promising therapeutic target for lycorine against HCC.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huadong Zhao, Ying Chen, Lu Qian, Luyang Du, Xue Wu, Ye Tian, Chao Deng, Shuai Liu, Wenwen Yang, Chenxi Lu, Yan Zhang, Jun Ren, Yang Yang
Summary: This study evaluates the effect of LYC pre- and post-treatment in a septic mouse model and its potential mechanism. LYC pretreatment attenuates myocardial injury by improving survival rate, sepsis score, blood indicators, cardiac function, inhibiting inflammation and oxidative stress, improving mitochondrial function, modulating ER stress, and activating AMPK pathway. LYC posttreatment also has slight protective effects on septic myocardial injury, but not as ideal as pretreatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Rong Wang, Yantong Liu, Sheng Xu, Jie Li, Jiayu Zhou, Ren Wang
Summary: The study identified an ABC transporter LaABCB11 from Lycoris aurea that functions in the transport of lycorine, potentially playing a role in the translocation and accumulation of lycorine from leaves and bulbs to roots. The transporter increased yeast cells' tolerance to lycorine and reduced lycorine accumulation in transformants compared to control or mutant yeast. LaABCB11 was found to be associated with the plasma membrane and mainly expressed in the phloem of leaves and bulbs, as well as in the cortical cells of roots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Huda Mohammed Alkreathy, Ahmed Esmat
Summary: Lycorine inhibits TAA-induced liver fibrosis in rats partly through its antioxidative and anti-inflammatory effects, as well as the inhibition of STAT3 signaling.
Article
Plant Sciences
Samuel Toluwani Akinyele, Christianah Abimbola Elusiyan, Nusrat Omotayo Omisore, Clement Oladapo Adewunmi
Summary: The leaf and bulb extracts of Crinum jagus showed moderate antimalarial activity, with the bulb extract being more effective. Lycorine and crinamine, isolated from the bulb extract, exhibited high antiplasmodial activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tiansi Xin, Michael B. Geeson, Hui Zhu, Zheng-Wang Qu, Stefan Grimme, Christopher C. Cummins
Summary: The structural characterization and scalable preparation of iron-phosphido complex FpP(Bu-t)(F) and its precursor FpP(Bu-t)(Cl) are reported, along with their relevance in organoiron catalytic cycle. The discovery of a more efficient catalytic system and successful synthesis of phosphirane compounds are also discussed.
Article
Biochemistry & Molecular Biology
Dana Atrahimovich, Raviv Harris, Ron Eitan, Menashe Cohen, Soliman Khatib
Summary: The study extracted and quantified the content of galantamine in bulbs of five cultivars of narcissus, and analyzed the alkaloids profile of the bulbs. Variations in the types of alkaloids were found among different cultivars.
Article
Cell Biology
Zu-Guo Zheng, Si-Tong Zhu, Hui-Min Cheng, Xin Zhang, Gang Cheng, Pyone Myat Thu, Supeng Perry Wang, Hui-Jun Li, Ming Ding, Lei Qiang, Xiao-Wei Chen, Qing Zhong, Ping Li, Xiaojun Xu
Summary: A small molecule called lycorine was discovered to inhibit the SREBF pathway through a novel mechanism without inducing ER stress or activating NR1H3, improving dyslipidemia and fatty liver disease. Lycorine promotes SCAP lysosomal degradation through the SQSTM1-mediated autophagy-independent lysosomal degradation (SMAILD) pathway, leading to SCAP degradation without autophagy.
Article
Pharmacology & Pharmacy
Jindan Qi, Mei Meng, Juntao Liu, Xiaoxiao Song, Yu Chen, Yuxi Liu, Xu Li, Zhou Zhou, Xiang Huang, Xiaohua Wang, Quansheng Zhou, Zhe Zhao
Summary: Pancreatic cancer is a highly metastatic and lethal tumor with a low survival rate. The lack of effective drugs in clinical settings is a major factor contributing to the high mortality. This study found that lycorine, a small molecule derived from a traditional Chinese medicinal herb, inhibited the growth and metastasis of pancreatic cancer cells, reduced neovascularization, and enhanced sensitivity to gemcitabine. The mechanism of action involves the degradation of Notch1 oncoprotein and downregulation of key vasculogenic genes.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alaa S. Abd-El-Aziz, Maysun R. Benaaisha, Amani A. Abdelghani, Rabin Bissessur, Laila H. Abdel-Rahman, Ahmed M. Fayez, Doaa Abou El-ezz
Summary: By attaching aspirin to organoiron dendrimers, the study successfully enhanced its anticancer activity, reduced toxicity, and demonstrated significant anti-inflammatory activity.
Review
Plant Sciences
Haoxiang Xiao, Xuezeng Xu, Luyang Du, Xiyang Li, Huadong Zhao, Zheng Wang, Lin Zhao, Zhi Yang, Shaofei Zhang, Yang Yang, Changyu Wang
Summary: This article reviews and discusses the effects and mechanisms of lycorine in the treatment of multi-organ dysfunction, especially sepsis. By regulating autophagy and inducing cancer cell apoptosis, as well as exhibiting anti-inflammatory, antifungal, antiviral, antimalarial, and antitumor effects, lycorine can ameliorate organ damage. Research has found that lycorine has an important effect on organ damage in sepsis. Lycorine, as a promising natural organ protective agent, provides a new theoretical basis for the treatment of organ protection, especially in sepsis.
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
