A highly stereocontrolled asymmetric total synthesis of epimer of (+)-7-deoxypancratistatin

A highly stereocontrolled asymmetric total synthesis of epimer of (+)-7-deoxypancratistatin has been achieved from readily available starting materials via unified strategy employing Sharpless asymmetric dihydroxylation, ring closing metathesis, Overman rearrangement, hydrogenolysis and Bischler-Napieralski reaction in 15 purification steps with 15% overall yield. (C) 2013 Elsevier Ltd. All rights reserved.