Review
Chemistry, Applied
Sadhna Bansal, Anand B. Shabade, Benudhar Punji
Summary: This review provides a comprehensive overview of C(sp(2))-H/C(sp(2))-H oxidative coupling of (hetero)arenes catalyzed by 3d transition metals, which is widely applied for the construction of (hetero)biaryls and holds significant importance in drug discovery, biology, and material sciences.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Linxi Yao, Alemayehu Gashaw Woldegiorgis, Shaoying Huang, Yongtao Wang, Xufeng Lin
Summary: We report a highly enantioselective desymmetrization reaction for the synthesis of axially chiral biaryl N-oxides by atroposelective C-H iodination using a chiral catalyst coordinated by N-benzoyl-l-phenylalanine. A broad range of products were obtained in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). The products could be synthesized in gram scale, and one of them was shown to be a powerful organocatalyst in asymmetric allylation reaction. Mechanistic evidence and DFT calculations provide insights into the factors leading to high reactivity and excellent enantiocontrol in this reaction.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Arup Dalal, Srinivasarao Arulananda Babu, Shefali Banga
Summary: A Pd(II)-catalyzed bidentate DG-aided C-H arylation method was reported to construct a collection of polyaryl motifs (pi-extended biaryls) in a single operation. This method enriches the library of polyaryls and demonstrates significance in synthesizing biologically active compounds and precursors of functional materials.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Lisa Marx, Daniel Lamberty, Sabine Choppin, Francoise Colobert, Andreas Speicher
Summary: This study presents an atroposelective macrocyclization process using an oxidative Heck system to achieve the first atropo-enantiopure synthesis of isoriccardin C, which demonstrates a new strategy for synthesizing biologically active optical isomers.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Donghui Guo, Qiupeng Peng, Bei Zhang, Jian Wang
Summary: The novel method described in this report allows for the atroposelective generation of axially chiral amino esters using hemiaminals formed in situ, with a wide substrate scope, good functional group tolerance, and rapid assembly of axially chiral amino esters with high enantioselectivities in good to high yields.
Review
Chemistry, Organic
Jonas F. Goebel, Zhongyi Zeng, Lukas J. Goossen
Summary: The article summarizes recent advances in the synthesis of biaryls through electrooxidative processes, with a particular focus on electrooxidative C-H/C-M couplings and dehydrogenative couplings.
SYNTHESIS-STUTTGART
(2022)
Article
Chemistry, Multidisciplinary
Si-Hua Hou, Adriana Y. Prichina, Guangbin Dong
Summary: The development of a deconstructive strategy for the first asymmetric synthesis of (-)-thebainone A was described, utilizing an enantioselective C-C bond activation and a C-O bond cleavage reaction. The newly optimized conditions show broad substrate scope and excellent enantioselectivity (up to 99.5:0.5 er). The synthesis of (-)-thebainone A was completed by taking advantage of boron-mediated ether bond cleavage through two complementary routes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Santosh Kumar Keshri, Suchithra Madhavan, Manmohan Kapur
Summary: Transition-metal catalysis has revolutionized organic synthesis by enabling efficient C-C and C-heteroatom bond formation. To functionalize nonbiased C-H bonds, various strategies have been developed, including the use of directing groups and substrate modification.
Article
Chemistry, Organic
Prabhakar Singh, Srinivasarao Arulananda Babu
Summary: This study reports the Pd(II)-catalyzed dC(sp(2))-H (ortho) functionalization of phenylalaninol scaffolds directed by picolinamide. Various arylated, alkylated, benzylated derivatives of phenylalaninol scaffolds were successfully synthesized. The hydrolysis of the picolinamide moiety and synthetic utility of the arylated substrates were investigated. The preparation of modified Matijin-Su derivatives using the arylated phenylalaninol compounds was also demonstrated.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Organic
Uros Todorovic, Immo Klose, Nuno Maulide
Summary: Thiocyanates, a versatile building block in organic synthesis, can be easily accessed through an interrupted Pummerer reaction of sulfoxides. This dealkylative functionalization can proceed under mild conditions by electrophilic activation of the sulfoxide partner, and the resulting thiocyanate can be used as a handle for diversification in a straightforward one-pot procedure.
Article
Chemistry, Organic
Hee Chan Noh, Cheol-Eui Kim, Kyungsup Lee, Dongwook Kim, Phil Ho Lee
Summary: A regioselective B(4)-alkenylation method has been developed using o-carboranyl sulfoxonium ylides and alkynes through B(4)-H activation catalyzed by Iridium(I). Sequential B(4)- and B(6)-alkenylation reactions resulted in the synthesis of B(3,5)-dialkenylated o-carboranyl sulfoxonium ylides in one pot. This method allows the introduction of two alkenyl groups at positions 3 and 5 of the carborane, with the sulfoxonium ylide serving as a directing group that can be further functionalized to B-alkenylated o-carboranyl trichloromethyl ketones.
Article
Chemistry, Physical
Zhenyuan Lin, Huahui Wang, Qinghua Wu, Junxuan Lin, Xucong Guo, Manqi Chen, Lu Chen, Yibiao Li, Chengshuo Shen, Min Zhang
Summary: By using eosin Y as a catalyst, this study demonstrates a photothermally induced decarbonylative aryl C-H arylation with aldehydes. The reaction is simple, solvent-free, and does not require 1,2-dinitrobenzene additive. It also tolerates previously unsuccessful functionalities. In addition to aryl aldehydes, alkyl aldehydes are also compatible. Mechanistic investigations reveal the reaction pathway involving aldehyde decarbonylation, regioselective addition, and oxidation.
JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Organic
Vikki N. Shinde, Krishnan Rangan, Dalip Kumar, Anil Kumar
Summary: A Rh(III)-catalyzed dehydrogenative annulation and spirocyclization of 2-arylindoles and 2-(1H-pyrazol-1-yl)-1H-indole with maleimides has been developed, providing highly functionalized compounds. The reaction methodology has broad substrate scope, good functional group tolerance, and is simple and scalable. The annulated product of 2-(1H-pyrazol-1-yl)-1H-indole showed significant red-shift and high absorption and emission values compared to 2-phenylindole.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ji-Min Yang, Yu-Kun Lin, Tao Sheng, Liang Hu, Xin-Pei Cai, Jin-Quan Yu
Summary: Regiocontrol is challenging in traditional cycloaddition reactions between unsaturated carbon compounds. This study reports a regio-controllable synthesis of benzocyclobutenes (BCBs) through a palladium-catalyzed double C-H activation of adjacent methylene units in carboxylic acids using bidentate amide-pyridone ligands. This method allows for the synthesis of diversely functionalized BCBs and hetero-BCBs found in drug molecules and bioactive natural products.
Article
Chemistry, Multidisciplinary
Vinayak Hanchate, Sudharshan Nagabhushana Reddy, Anil Kumar, Kandikere Ramaiah Prabhu
Summary: The reactivity of sulfoxonium ylide with allyl carbonates and allyl carbamates diverges. Rh(iii)-catalyzed C-H activation and cyclization of sulfoxonium ylide with ally esters leads to the formation of a cyclopropane-fused tetralone derivative via cascade C-H activation, (4+2) annulation, and cyclopropanation. A similar reaction of sulfoxonium ylide with allyl carbamates forms a C3-substituted indanone derivative through a rare and interesting domino C-H activation and (4+1) annulation in which allyl carbamate acts as a C1-synthon.
CHEMICAL COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Neeraj Kumar, Mini Sharma, Neeti Aggarwal, Sanjiv Sharma, Malay Sarkar, Balraj Singh, Navneet Sharma
Summary: This study evaluated diffusion and dynamic contrast-enhanced MRI parameters in differentiating malignant from benign pulmonary lesions. Among the parameters, K-trans showed the highest diagnostic accuracy, while mean ADC and K-trans had similar sensitivity in predicting malignancy.
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2021)
Article
Chemistry, Applied
Pallavi Jain, Swati Sharma, Neeraj Kumar, Namita Misra
APPLIED ORGANOMETALLIC CHEMISTRY
(2020)
Article
Biochemical Research Methods
Neeraj Kumar, Damini Sood, Peter J. van der Spek, Hari S. Sharma, Ramesh Chandra
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Neeraj Kumar, Amardeep Awasthi, Anchala Kumari, Damini Sood, Pallavi Jain, Taru Singh, Neera Sharma, Abhinav Grover, Ramesh Chandra
Summary: The coronavirus pandemic has resulted in a large number of deaths worldwide, emphasizing the urgent need for effective treatments against COVID-19. This study explores the potential of combining the antitussive drug, noscapine, with antiviral drugs for treating the disease. The researchers found that the noscapine-hydroxychloroquine conjugate showed strong binding to the main protease of SARS-CoV-2, which is crucial for the virus's infection and progression. This combinatorial therapy could be further investigated as a potential treatment for COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Physical
Hitesh Sehrawat, Neeraj Kumar, Damini Sood, Loveneesh Kumar, Ravi Tomar, Sujata K. Dass, Ramesh Chandra
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Agronomy
K. S. Gill, N. Kumar, H. S. Randhawa, A. H. Carter, J. Yenish, C. F. Morris, B-K Baik, R. W. Higginbotham, S. O. Guy, D. A. Engle, X. M. Chen, T. D. Murray, D. J. Lyon
JOURNAL OF PLANT REGISTRATIONS
(2020)
Article
Biochemistry & Molecular Biology
Neeraj Kumar, Damini Sood, Aditya Gupta, Niraj Kumar Jha, Pallavi Jain, Ramesh Chandra
BIOSCIENCE REPORTS
(2020)
Article
Pharmacology & Pharmacy
Neeraj Kumar, Damini Sood, Snigdha Singh, Suveen Kumar, Ramesh Chandra
Summary: The study presents a high bio-recognizing DNA aptamer designed for diagnosis and therapeutic role against HHV-5, showing potent binding affinity to gB and potential regulatory role in virus blockade.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Niraj Kumar Jha, Shreesh Ojha, Saurabh Kumar Jha, Harish Dureja, Sachin Kumar Singh, Shakti D. Shukla, Dinesh Kumar Chellappan, Gaurav Gupta, Shanu Bhardwaj, Neeraj Kumar, Madhan Jeyaraman, Rashmi Jain, Sathish Muthu, Rohan Kar, Dhruv Kumar, Vineet Kumar Goswami, Janne Ruokolainen, Kavindra Kumar Kesari, Sandeep Kumar Singh, Kamal Dua
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has not only respiratory manifestations, but also affects other organs including the nervous system. Neurological symptoms such as sensory and motor impairments, as well as cerebrovascular diseases, have been reported.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Neeraj Kumar, Nikita Admane, Anchala Kumari, Damini Sood, Sonam Grover, Vijay Kumar Prajapati, Ramesh Chandra, Abhinav Grover
Summary: This study predicted highly efficacious CTL epitopes for a potential vaccine against COVID-19 through advanced immunoinformatics analysis, and molecular docking and dynamics simulation confirmed the strong immune response elicited by the CTL vaccine candidate.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Maria Itria Ibba, Neeraj Kumar, Craig F. Morris
Summary: The study identified and characterized an extra soft kernel phenotype in soft kernel durum wheat, with two significant QTLs identified for improving kernel hardness and potentially transferable to other wheat varieties.
Article
Chemistry, Physical
Hitesh Sehrawat, Neeraj Kumar, Damini Sood, Loveneesh Kumar, Ravi Tomar, Ramesh Chandra
Summary: This study demonstrates a stable interaction between a noscapine-based ionic liquid and human hemoglobin, highlighting its significance in drug transport and targeting.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Neurosciences
Muhammad Bello Usman, Shreesh Ojha, Saurabh Kumar Jha, Dinesh Kumar Chellappan, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, Shubhadeep Roychoudhury, Neeraj Kumar, Firdos Alam Khan, Harish Dureja, Vijay Upadhye, Flavia Zacconi, Pragya Prasanna, Kavindra Kumar Kesari, Ghulam Md Ashraf, Athanasios Alexiou, Niraj Kumar Jha
Summary: Computational approaches to study neuronal impairment are rapidly advancing, requiring the development of databases and tools for data analysis. It is important to update and train young professionals, and this review aims to provide an overview of biological databases and analytical tools.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Proceedings Paper
Engineering, Mechanical
Susant Kumar Sahu, N. Sendhil Kumar, T. Ganapathy
ADVANCES IN MECHANICAL ENGINEERING, ICRIDME 2018
(2020)
Article
Chemistry, Multidisciplinary
Heerak Chugh, Pramod Kumar, Neeraj Kumar, Rajesh K. Gaur, Gagan Dhawan, Ramesh Chandra
Summary: In this study, the binding of Noscapine with human hemoglobin was investigated using various experimental methods, which showed a feasible interaction and formation of a binding complex between the two molecules. This interaction led to a change in the secondary structure of Hb and was further verified to be stable at the molecular level through docking studies.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
