Click chemistry inspired structural modification of azole antifungal agents to synthesize novel 'drug like' molecules

A new class of 'drug like' 1,4-disubstituted-1,2,3-triazoles is synthesized using one-pot reaction of sodium azide, alpha-bromo ketones, and alkynes in PEG-400/water (1:1, v/v) under the click chemistry reaction condition followed by reduction of keto group and alkylation. The method is simple, efficient and gives good yield of novel 1,2,3-triazole derivatives. (C) 2012 Elsevier Ltd. All rights reserved.