☆ 4.4 Article

Nano crystalline ZnO catalyzed one pot multicomponent reaction for an easy access of fully decorated 4H-pyran scaffolds and its rearrangement to 2-pyridone nucleus in aqueous media

TETRAHEDRON LETTERS (2012)

期刊

TETRAHEDRON LETTERS

卷 53, 期 35, 页码 4687-4691

出版社

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.tetlet.2012.06.086

关键词

Nano structured ZnO; 4H-Pyrans; 3,4-Dihydropyridin-2-one; Organic acid catalyzed rearrangement

类别

Chemistry, Organic

资金

University of Calcutta
CSIR, New Delhi, India [09/028(0768)/2010]
UGC
DST-FIST, India

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摘要

A green and highly efficient protocol has been developed for the synthesis of 4H-pyran scaffolds installing a one-pot three-component coupling reaction of an aldehyde, malononitrile, and a 1,3-diketo compound using nano structured ZnO as the catalyst in aqueous alcoholic medium. A greener method to synthesize 3,4-dihydropyridin-2-one has also been developed by rearranging 4H-pyran derivatives in aqueous medium applying p-TSOH as the right catalyst source. A wide spectrum of functional groups was tolerated in both the developed synthetic protocols with good to excellent yield of the targeted molecules. (c) 2012 Elsevier Ltd. All rights reserved.

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