CuCl catalyzed green and efficient one-pot synthesis of aminoindolizine frameworks via three-component reactions of aldehydes, secondary amines, and terminal alkynes in PEG

CuCl catalyzes efficient synthesis of aminoindolizine scaffolds by one-pot reactions in PEG of pyridine- or quinoline-2-carboxaldehydes with secondary amines and terminal alkynes via tandem C H activation, coupling, and cyclization reactions. The reactions are easy to perform, atom-economic, environment friendly, broad in scope, and allow the generation of a number of biologically potent aminoindolizine frameworks from readily accessible starting materials. (c) 2012 Elsevier Ltd. All rights reserved.