期刊
TETRAHEDRON LETTERS
卷 52, 期 52, 页码 7135-7137出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.10.109
关键词
Click reaction; Postsynthetic-modification method; Oligodeoxynucleotides; Alkali treatment
We characterized click reaction between oligodeoxynucleotides (ODNs) possessing acetylene groups at the phosphate unit and azide compounds. Cu(I)-catalyzed cycloaddition proceeded efficiently to form the corresponding functional ODNs. The resulting ODNs could be converted into ordinary ODNs by treatment with aqueous methylamine. The present method successfully achieved a reversible modification of ODNs. (C) 2011 Elsevier Ltd. All rights reserved.
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