期刊
TETRAHEDRON LETTERS
卷 52, 期 44, 页码 5855-5857出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.08.152
关键词
NAD analogs; Malic enzyme; Alcohol dehydrogenase; Promiscuity
Thirteen 1,2,3-triazole moiety-containing NAD analogs were synthesized and evaluated as redox cofactors. Noticeable enzymatic activities were observed when these analogs were employed as cofactors for malic enzyme or alcohol dehydrogenase. Our results indicated that the natural NAD-dependent oxidoreductases possessed flexible NAD binding pockets. (C) 2011 Elsevier Ltd. All rights reserved.
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