Cross-coupling of Grignard reagents with alkyl halides or tosylates by the use of nickel or palladium containing perovskite

Nickel and palladium-containing perovskites, LaFe0.8Ni0.2O3 (LFNO) and LaFe0.95Pd0.05O3 (LFPO), could be employed as effective catalyst sources for the cross-coupling of nonactivated alkyl halides and tosylates with Grignard reagents in the presence of conjugated dienes. The reaction proceeded efficiently at room temperature or below using only ca. 1 mol %of catalysts with respect to Ni or Pd and the perovskites were reused without considerable loss of activity. (C) 2010 Elsevier Ltd. All rights reserved.