Article
Engineering, Chemical
Carmellina Daniela Badiceanu, Catalina Mares, Diana Camelia Nuta, Speranta Avram, Constantin Draghici, Ana-Maria Udrea, Irina Zarafu, Cornel Chirita, Marilena Viorica Hovanet, Carmen Limban
Summary: Novel phthalimide derivatives and hexahydrophthalimide derivative have been successfully synthesized and their chemical structures were elucidated. The compounds exhibited antioxidative activity, with compound 1b being the most active. Bioinformatics analysis predicted their pharmacokinetics and pharmacodynamics profiles, showing good intestinal absorption, BBB and CNS permeabilities, and important molecular targets for antioxidant activity.
Article
Chemistry, Organic
Ajay Kumar Chinnam, Richard J. Staples, Jean'ne M. Shreeve
Summary: This paper reports the synthesis and characterization of two new derivatives with high crystal densities, with their energetic properties investigated. All compounds were fully characterized by various analytical techniques.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Fengfan Liu, Chen Yang, Shaoguang Li, Xiaoqi Wu, Keming Xue, Yibo Zhou, Xiaobing Liang, Xiang Cheng, Qiwen Shi, Weike Su
Summary: A series of platinum compounds with fluoro-functional groups were designed and synthesized, and specific compounds were found to exhibit better cytotoxic activity in antitumor activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Pablo Rayff da Silva, Nadjaele de Melo Apolinario, Simone Angela Soares da Silva, Maria Elaine Cristina Araruna, Thassia Borges Costa, Yvnni M. S. de Medeiros e Silva, Teresinha Goncalves da Silva, Ricardo Olimpio de Moura, Vanda Lucia dos Santos
Summary: This study evaluated the anti-inflammatory potential of the compound JR19 and found that it can exert its anti-inflammatory effects through the nitric oxide pathway and cytokine signaling.
Article
Chemistry, Organic
Xiaoling Liu, Haimei Liu, Chang Bian, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Yingpeng Su, Xiaobo Lv, Yulai Hu
Summary: A new and efficient method for the synthesis of polysubstituted 3-trifluoromethyl-1,2,4-triazolines and their derivatives is described, involving a tandem addition/cyclization reaction between trifluoromethylN-acylhydrazones and cyanamide. The method offers mild reaction conditions, a broad substrate scope, good product yields, and atom economy.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ryoko Oyama, Ryuei Hayashi, Manabu Abe
Summary: Transient radical species generated in the photolysis of 2-(4-nitrophenyl)-1H-indoly-3-methyl (NPIM) derivatives were studied using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) spin trapping studies. The structures of the DMPO spin adducts were determined through electron paramagnetic resonance spectroscopy, mass spectrometry, and quantum chemical calculations. The results revealed homolytic bond cleavage in the photolysis of NPIM derivatives.
Article
Biochemistry & Molecular Biology
Shun Tu, Ting-Jian Zhang, Yi Zhang, Xu Zhang, Zhen-Hao Zhang, Fan-Hao Meng
Summary: This study synthesized two series of amide-based XO inhibitors, with compound 3i showing the most promising in vitro inhibitory potency and hypouricemic effect. Molecular simulations provided insights into the interaction modes of representative compounds, supporting compound 3i as a lead for further exploration of amide-based XO inhibitors.
BIOORGANIC CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Xiujun Gao, Ning Sui, Quan Wang, Lingyun Pan, Xiaochun Chi, Hanzhuang Zhang, Ran Lu, Zhihui Kang, Yinghui Wang
Summary: The study investigated the photo-physical properties of an organic molecule with two-photon fluorescence capabilities through spectroscopy tests, revealing their dependence on solvent polarity and temperature. These organic molecules show potential for applications in LEDs and their optoelectronic properties are affected by factors such as solvent polarity and temperature.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Biochemistry & Molecular Biology
Dominika Szkatula, Edward Krzyzak, Paulina Stanowska, Magdalena Duda, Benita Wiatrak
Summary: In this study, new isoindoline-1,3-dione derivatives were synthesized and characterized using elemental and spectral analysis methods. Their physicochemical and biological properties, including antioxidant and anti-inflammatory activities, were further investigated. The study also demonstrated interactions inside the active site of cyclooxygenases through molecular docking analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Kayed Abu-Safieh, Musa El-Barghouthi, Monther A. Khanfar, Bader A. Salameh, Islam S. Al-Aqrabawi, Baker Jawabrah Al Hourani, Basem F. Ali
Summary: The title compound with three independent molecules in the asymmetric unit forms a compact 3D supramolecular structure through hydrogen bonding. Molecular docking techniques were used to study interactions with proteins and interpret cytotoxic activities against cancer cell lines. Strong interactions were observed between the title compound and a closely related structure with modifications at position 5 in the pyrazole ring.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Applied
Biao Zhang, Pan Zhou, Hui Xu, Jiuzhong Huang, Yulin Sun, Donghan Liu, Fuchao Yu
Summary: A copper(II)-mediated intermolecular radical [3+2] annulation of N,N-dimethyl enaminones has been developed, providing access to 5-acyl-3-furancarboxaldehydes with good yields and broad substrate scope. This reaction allows the formation of multiple new bonds through a radical cyclization process, showing potential application value in industry as demonstrated by gram-scale synthesis and application research.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Jian-Qiang Zhao, Xue-Man Zhang, Yu-Ying He, Qiao-Qiao Peng, Han-Wen Rao, Yan-Ping Zhang, Zhen-Hua Wang, Yong You, Wei-Cheng Yuan
Summary: This study describes an organocatalytic asymmetric [3 + 2] cyclo-addition of beta-trifluoromethyl enones with 3-(N-2,2,2-trifluoroethyl) benzothiophene ketimines and 2-(N-2,2,2-trifluoroethyl) benzothiophene ketimines for the first time. A wide range of vicinally bis(trifluoromethyl)-substituted spiro pyrrolidine-benzothiophenones were obtained with excellent stereocontrol, including those with four contiguous stereocenters in the spirocyclic benzothiophenone moiety.
Article
Chemistry, Organic
Hefei Yang, Shu-Ning Lu, Yufei Song, Zhengkai Chen, Xiao-Feng Wu
Summary: A simple and direct method for synthesizing 3-trifluoromethyl-1,2,4-triazoles via copper-mediated [3 + 2] cycloaddition of trifluoroacetimidoyl chlorides and N-isocyanoiminotriphenylphosphorane (NIITP) has been described. The use of Mo(CO)(6) as an effective promoter to activate NIITP allows for easily accessible reagents, mild reaction conditions, a wide substrate scope, high efficiency, and reproducibility on a 3 mmol scale.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Pharmacology & Pharmacy
Qi Wang, Bixi Tang, Dandan Sun, Ying Dong, Yinchun Ji, Huanyu Shi, Liwei Zhou, Yueyue Yang, Menglan Luo, Qian Tan, Lin Chen, Yue Dong, Cong Li, Rongrong Xie, Yi Zang, Jingkang Shen, Bing Xiong, Jia Li, Danqi Chen
Summary: Idiopathic pulmonary fibrosis (IPF) is a serious chronic lung disease with inaccurate diagnosis, limited clinical therapy, and high mortality. The discoidin domain receptors (DDR) have been identified as promising drug targets for IPF treatment, and compound 47 shows potential as a candidate for further drug development.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Medicine, Research & Experimental
Carlos Eduardo de Castro Alves, Georgyi Koidan, Anastasiia N. Hurieva, Alice de Freitas Gomes, Regiane Costa de Oliveira, Allyson Guimaraes Costa, Antonio Luiz Ribeiro Boechat, Serhii Zahorulko, Aleksandr Kostyuk, Gemilson Soares Pontes, Andre Correa de Oliveira
Summary: This study aimed to investigate the anticancer and immunomodulatory potential of a novel compound in the treatment of leukemia. The results showed that the compound exhibited selective cytotoxicity against cancer cells without significant cytotoxic effects on non-cancerous cells. It also demonstrated immunomodulatory activities. These findings suggest that the compound has promising potential for the treatment of acute and chronic myeloid leukemias.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
