期刊
TETRAHEDRON LETTERS
卷 51, 期 24, 页码 3193-3196出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.04.038
关键词
Enaminones; Pyrazoles; Grinding; Solvent-free conditions
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
A series of NH-pyrazoles was efficiently synthesized from the reaction of beta-dimethylaminovinylketones ([(RC)-C-1(O)C(R-2)=CHN(Me-2)], where R-1 = Me, Ph, 3-MeO-Ph, 4-Me-Ph, 4-MeO-Ph, 4-F-Ph, 4-Cl-Ph, 4-Br-Ph, 4-O2N-Ph, fur-2-yl, thien-2-yl; R-2 = H, 2-MeO-Ph; R-1, R-2 = -(CH2)(3)C(O)-) and hydrazine sulfate in solid state on grinding in the presence of p-toluenesulfonic acid (PTSA). Most of the reactions proceeded smoothly at room temperature under solvent-free conditions. In comparison with the classical reaction conditions, which employ molecular solvent (ethanol), this new synthetic method has the advantages of shorter times, higher yields, mild reaction conditions as well as being environmentally friendly. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据