期刊
TETRAHEDRON LETTERS
卷 51, 期 50, 页码 6500-6502出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.138
关键词
N-Acyl-homoserine lactone; Quorum-sensing; Prophenol-zinc-catalyzed reaction; Asymmetric transfer hydrogenation; Ethyl diazoactate
资金
- DST, New Delhi, India [SR/SI/OC-12/2007]
- CSIR (New Delhi)
A concise enantioselective total synthesis of (2S,3'R,7'Z)-N-(3'-hydroxy-7'-tetradecenoyl)-homoserine lactone is described. Key feature of this protocol is a catalytic asymmetric hydrogenation and a prophenol-zinc-catalyzed diazo addition to imine reaction as genesis of chirality. Moreover, flexibility is built in the synthesis to generate enantioenriched analogs using catalytic amount of enantioenriched C(2)-symmetric ligands. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据