Article
Chemistry, Multidisciplinary
Barbara Lesniewska, Anthony W. Coleman, Kinga Suwinska
Summary: Para-sulfonato-calix[4]arene has been proven to be a great receptor for biomolecules. In this study, four complexes of para-sulfonato-calix[4]arene with bioactive molecules were presented and their structures were determined by X-ray diffraction. The complexes accommodate biomolecules within the hydrophobic cavity and are stabilized by noncovalent interactions.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Analytical
Ermanno Vasca, Francesco Siano, Tonino Caruso
Summary: A fluorescence sensing method based on host-guest molecular recognition is proposed for the detection of widely used herbicides paraquat and diquat. The method utilizes calix[6]arene derivatives containing anthracene or naphthalene as pendant fluorophore to recognize paraquat and diquat in hydroalcoholic solution and shows a broad linear response range. The method has been successfully applied to the determination of paraquat in drinking water samples.
Review
Chemistry, Multidisciplinary
Takehiro Hirao, Takeharu Haino
Summary: This review introduces the research directions for the synthesis of supramolecular fullerene polymers, including the linear, networked, helical arrays directed by the use of calix[5]arene-fullerene interactions, and the investigation of the calix[5]arene-fullerene interaction for control over the chain structures of covalent polymers.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Takehiro Hirao, Naoka Fujii, Yoshiki Iwabe, Takeharu Haino
Summary: Self-sorting supramolecular polymerization was achieved using chiral calix[5]arene hosts and a dumbbell-shaped fullerene guest, leading to the formation of helical supramolecular fullerene polymers. The controlled supramolecular polymerization was confirmed through diffusion-ordered H-1 NMR (DOSY) and circular dichroism (CD) studies.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Varun Rawat, Arkadi Vigalok
Summary: Fluorescent calix[4]arene scaffolds with electron-rich carbazole moiety conjugated at the lower rim have been prepared. The electronic properties of the distal phenolic ring play a major role in the fluorescence quenching in the presence of the N-methyl pyridinium guest. Introducing an electron-donating piperidine fragment into that ring significantly increases the host-guest interactions, while introducing the same fragment into the proximal phenolic ring weakens the fluorescence response.
Article
Chemistry, Organic
Nicolas Nyssen, Daniela Ajami, Adrien Ardelean, Florent Desroches, Jing Li, Michel Luhmer, Olivia Reinaud, Ivan Jabin
Summary: The study on a molecular capsule based on a calix[6]arene core reveals unique coordination modes to prevent guest molecule exchange and evaluates the impact of different closing mechanisms on binding ability. The selective binding of different ligands through metal ion coordination highlights the importance of rigidification of receptor conformation. However, increased rigidity may weaken host-guest interactions, affecting the induced-fit behaviors observed in the parent compound.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Cristina Decavoli, Chiara L. Boldrini, Federica Faroldi, Laura Baldini, Francesco Sansone, Anna Ranaudo, Claudio Greco, Ugo Cosentino, Giorgio Moro, Norberto Manfredi, Alessandro Abbotto
Summary: Novel integrated photosensitizer-catalyst dyads based on robust host-guest interactions have been developed, showing twice greater efficiency in current photogeneration compared to traditional architecture. The enhanced performance is attributed to optimization of distances between the centers of photosensitizer, catalyst, and semiconductor.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Seung Hyeon Kim, Yerim Yeon, Areum Lee, Vincent M. Lynch, Qing He, Jonathan L. Sessler, Sung Kuk Kim
Summary: A calix[4]arene compound 1 functionalized with amidoindole groups on the upper rim and with propyl groups on the lower rim was synthesized. It was found that compound 1 can bind the lithium cation and the chloride anion concurrently with enhanced affinity. Additionally, compound 1 can selectively extract and solubilize LiCl and LiBr into chloroform.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Stefano Volpi, Aishling Doolan, Laura Baldini, Alessandro Casnati, Peter B. Crowley, Francesco Sansone
Summary: This study tested a rigid cone calix[4]arene with anionic alanine units as a ligand for cytochrome c, and NMR spectroscopy revealed the presence of two binding sites at lysine residues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Masayuki Morie, Ryo Sekiya, Takeharu Haino
Summary: In this study, a triple-stranded metallohelicate was formed by self-assembly of 5,17-difunctionalized calix[4]arenes and metal cations, showing good encapsulation properties and selectivity. CD spectroscopy confirmed the preference of the metallohelicate for guest molecules. NMR, UV-vis experiments, and molecular mechanics calculations revealed the interaction mechanism between the metallohelicate and guest molecules.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Mamina Bhol, Guilhem Claude, Maximilian Roca Jungfer, Ulrich Abram, Malaichamy Sathiyendiran
Summary: In this study, calix[4]arene-analogous technetium supramolecules and rhenium-based macrocycles were successfully assembled by using specific ligands and starting materials. The structures of these molecules were characterized in detail.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Lijun Mao, Fengwu Li, Lingzi Huang, Xin Qu, Ke Wang, Yanjing Zhang, Da Ma
Summary: A new type of macrocyclic arene, calix[n]phenoxazines, based on phenoxazine compounds, has been developed. Calix[3]phenoxazines with different substitutes on nitrogen atoms and methylene bridges have been synthesized with a yield of 30%-70%. The study reveals that calix[3]phenoxazines possess electron-rich cavities, allowing them to selectively encapsulate suitable electron-deficient guests through multiple noncovalent interactions.
Article
Polymer Science
Zhanqi Cao, Fan Yang, Dongpu Wu, Lulu Wu, Lijie Liu, Guoxing Liu, Xiaochuan Li, Xin Zheng, Xianfu Zheng, Dahui Qu
Summary: A novel pillar[5]arene-bridged monomer with TPE and nitrile group was synthesized and it formed supramolecular aggregates based on the host-guest interaction. The supramolecular aggregates exhibited significant aggregation-induced emission due to the restricted intramolecular rotation of the TPE core.
Article
Chemistry, Multidisciplinary
Juan-Juan Li, Rui-Xue Rong, Yan Yang, Zong-Ying Hu, Bing Hu, Ying-Ying Zhao, Hua-Bin Li, Xin-Yue Hu, Ke-Rang Wang, Dong-Sheng Guo
Summary: Host-guest drug delivery systems (HGDDSs) have been studied to modify therapeutic agents and improve treatment effects. The targeting ability of HGDDSs needs continuous improvement for the development of precision medicine. In this study, a lactose-modified azocalix[4]arene (LacAC4A) was used as a triple targeting drug carrier for antitumor purposes. LacAC4A showed effective tumor growth suppression through passive targeting, active targeting, and stimuli-responsive targeting. This design principle provides a new material for drug delivery systems.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Ran Cen, Ming Liu, Jihong Lu, Weifang Zhang, Jingjing Dai, Xi Zeng, Zhu Tao, Xin Xiao
Summary: A novel fluorescent sensor was prepared using sulfonated calix[4]arene (SC4A) and rhodamine B (RB) as a structure-directing agent, showing sensitivity and selectivity towards Fe3+ ions through fluorescence quenching. The host-guest complex exhibited a triangular branch structure and demonstrated potential for monitoring metal ion pollutants.
CHINESE CHEMICAL LETTERS
(2022)
Review
Pharmacology & Pharmacy
Dilipkumar Pal, Souvik Mukherjee, In-Ho Song, Satish B. Nimse
Summary: Alzheimer's disease is a common form of dementia caused by cognitive function impairment, with research suggesting the involvement of GSK-3 in the hyper-phosphorylation of tau proteins, making it a potential target for AD treatment. Inhibitors of GSK-3 have received significant attention for their potential therapeutic applications in AD and other diseases.
CURRENT DRUG TARGETS
(2021)
Article
Chemistry, Analytical
Satish Balasaheb Nimse, Keum-Soo Song, Shrikant Dashrath Warkad, Taisun Kim
Summary: The study introduces a new method for detecting multiple pathogens on a single platform with highly sensitive and specific DNA hybridization. Experimental results demonstrate that the method can efficiently detect and discriminate in clinical samples.
Review
Biotechnology & Applied Microbiology
Sanju Singh, Satish B. Nimse, Doniya Elze Mathew, Asmita Dhimmar, Harshal Sahastrabudhe, Apexa Gajjar, Vishal A. Ghadge, Pankaj Kumar, Pramod B. Shinde
Summary: Melanin, a group of biopolymers, has potential applications in medical sciences, cosmeceutical, bioremediation, and bioelectronic applications. Biosynthesis of melanin in fungi and bacteria mainly occurs through two pathways, leading to different types of melanin with different synthesis enzymes. Research on increasing melanin yield for large-scale production is beneficial for various applications.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Chemistry, Medicinal
Supriyo Saha, Dilipkumar Pal, Satish Balasaheb Nimse
Summary: This manuscript focuses on the importance of indazole derivatives in the treatment of various gastrointestinal diseases. Different indazole derivatives play a critical role in the treatment of different diseases such as IBS, diarrhea, metabolic syndrome, and gastrointestinal cancers. By analyzing the receptors associated with gastrointestinal disorders, it was found that indazole derivatives can effectively interact with the receptors.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Jung-Seop Lee, In-ho Song, Shrikant Dashrath Warkad, Gyu Seong Yeom, Pramod B. Shinde, Keum-soo Song, Satish Balasaheb Nimse
Summary: In this study, a series of 2,5-substituted-1H-benzo[d]imidazole derivatives were synthesized and it was demonstrated that compounds B15, B16, B19, and B20 exhibit excellent anticancer activity.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Chemistry, Analytical
Keum-Soo Song, Satish Balasaheb Nimse, Shrikant Dashrath Warkad, Jung-Hoon Kim, Hey-Jin Kim, Taisun Kim
Summary: Lung cancer is a leading cause of death globally. Low-dose computed tomography (LDCT) reduces lung cancer mortality by 20% compared to standard chest X-rays among current or heavy smokers, but has a high false-positive rate. This study presents a method based on biomarker detection to complement LDCT for detecting various stages of lung cancer.
Article
Chemistry, Analytical
Gyu Seong Yeom, In-ho Song, Shrikant Dashrath Warkad, Pramod B. Shinde, Taewoon Kim, Seong-min Park, Satish Balasaheb Nimse
Summary: The study successfully utilized the ABIA fluorescent probe and CysDDev device for highly sensitive detection of cysteine, achieving excellent results in simulated human urine as well as successful detection in intracellular assays.
Article
Biochemistry & Molecular Biology
Dilipkumar Pal, In-ho Song, Shrikant Dashrath Warkad, Keum-soo Song, Gyu Seong Yeom, Supriyo Saha, Pramod B. Shinde, Satish Balasaheb Nimse
Summary: This review presents the research advances on compounds containing indazole scaffolds as microtubule targeting agents based on articles published in the last two decades. Several compounds have shown potent microtubule inhibition and anticancer activity, with some of them having the lowest IC50 values observed in cell line studies.
BIOORGANIC CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Supriyo Saha, Gyu Seong Yeom, Satish Balasaheb Nimse, Dilipkumar Pal
Summary: The manuscript focuses on providing clues to enhance the innate immunity of coronavirus patients and protect them from new mutant strains and black fungus infections. Through molecular docking studies, potential therapeutic candidates for COVID-19 and drugs for treating black fungus infections were identified. The combined therapy of ledipasvir and itraconazole could be a better alternative for treating COVID-19 patients coinfected with black fungus.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Analytical
In-ho Song, Gyu Seong Yeom, Anil Kuwar, Satish Balasaheb Nimse
Summary: In this study, a benzimidazole-based compound and its derivative probe were synthesized for the highly selective detection and quantification of cysteine in human serum. The derivative probe showed high selectivity and sensitivity for cysteine and achieved lower detection limits compared to reported methods in serum samples.
Article
Biochemistry & Molecular Biology
Kundan Tayade, Gyu-Seong Yeom, Suban K. Sahoo, Horst Puschmann, Satish Balasaheb Nimse, Anil Kuwar
Summary: This study synthesized Schiff base compound 2 and determined its crystal structure and molecular structure. The antioxidant activity of this compound was confirmed through calculations and experiments. The compound exhibited excellent antioxidant activity and low cytotoxicity.
Article
Chemistry, Analytical
Prasad M. Sonawane, Neha Jain, Arkaprava Roychaudhury, Su Jeong Park, Vikas K. Bhosale, Mahesh B. Halle, Cheol-Hee Kim, Satish Balasaheb Nimse, David G. Churchill
Summary: This study introduces the synthesis and application of a highly sensitive fluorescence turn-on probe, Myco-OCl, for the specific and rapid detection of HOCl. The probe shows exceptional performance and has been successfully applied for live cell imaging and detection of HOCl in a zebrafish model.
Article
Chemistry, Analytical
Prasad M. Sonawane, Neha Jain, Arkaprava Roychaudhury, Su Jeong Park, Vikas K. Bhosale, Mahesh B. Halle, Cheol-Hee Kim, Satish Balasaheb Nimse, David G. Churchill
Summary: This study introduces a highly sensitive fluorescence turn-on probe, Myco-OCl, for detecting HOCl with exceptional specificity and rapid response. The probe has great potential for detecting HOCl in diverse physiological systems.
Article
Chemistry, Medicinal
Keum-soo Song, Satish Balasaheb Nimse, Junghoon Kim, Shrikant Dashrath Warkad, Taisun Kim
Summary: The developed ID-Checker enables highly specific delivery of anticancer agents to cancer cells through GLUT channels, resulting in cancer cell death within a short period of time without causing damage to normal cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Manohar Patil, Su Jeong Park, Gyu Seong Yeom, Ratnamala Bendre, Anil Kuwar, Satish Balasaheb Nimse
Summary: A Schiff base ligand FHE was synthesized and showed specific complex formation with Zn2+ ions, resulting in enhanced fluorescence. FHE demonstrated high sensitivity for detecting Zn2+ ions in living cells and environmental samples.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
