Article
Agriculture, Multidisciplinary
Mengying Lv, Lei Wang, Yujuan Guo, Jun Yao
Summary: This study evaluated the metabolic responses of various tissues in rats to TMG using H-1 NMR spectroscopy combined with chemometric and bioinformatics techniques. The results showed significant changes in liver metabolism, specifically related to amino acid, glutathione, energy, and lipid metabolism. It is important to note the potential cumulative effects of dietary TMG on tissues, especially the liver, when improving the quality control standard of cottonseed oil.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Organic
Jing Jiang, Yujian Mao, Yaoyu Lin, Jiayi Shen, Yinan Zhang
Summary: This article presents a total synthesis of hemigossypol through ligand-directed C-H oxygenations and completing the synthesis in 10 steps with a total yield of 9.5%. By adjusting the order of hydroxyl and isopropyl group installation, our strategy based on direct functionalization of a naphthalene ring shortens the route and improves efficiency compared to conventional approaches. This regiospecific approach holds promise for rapid access to diverse derivatives of gossypol for biological studies.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Plant Sciences
Lewis J. Martin, Elizabeth A. Cairns, Marika Heblinski, Charlotte Fletcher, James R. Krycer, Jonathon C. Arnold, Iain S. McGregor, Michael T. Bowen, Lyndsey L. Anderson
Summary: Based on ligand-based virtual screening, novel protein targets for phytocannabinoids were suggested, with Cannabichromene (CBC) and Delta(9)-tetrahydrocannabinolic acid (Delta(9)-THCA) identified as inhibitors of LDHA through noncompetitive mode of inhibition, binding within the nicotinamide pocket. This study highlights the potential therapeutic effects and molecular interactions of phytocannabinoids with LDHA enzymes.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Jia-Ling Lin, Xin Fang, Jian-Xu Li, Zhi-Wen Chen, Wen-Kai Wu, Xiao-Xiang Guo, Ning-Jing Liu, Jia-Fa Huang, Fang-Yan Chen, Ling-Jian Wang, Baofu Xu, Cathie Martin, Xiao-Ya Chen, Jin-Quan Huang
Summary: This study identified two dirigent proteins responsible for the biosynthesis of the two enantiomers of gossypol in cotton. Editing one of the dirigent proteins selectively removed the toxic (-)-gossypol in cotton seeds without affecting pest resistance. Our study offers insight into how plants control enantiomeric ratios and how to selectively modify the chemical spectra of cotton plants and thereby improve crop quality.
Review
Agriculture, Dairy & Animal Science
Wei-Kang Wang, Hong-Jian Yang, Yan-Lu Wang, Kai-Lun Yang, Lin-Shu Jiang, Sheng-Li Li
Summary: This review discusses the clinical signs of gossypol in ruminant animals and advances in the study of gossypol detoxification in the rumen. It also examines the regulatory roles of several key enzymes in gossypol detoxification and transformation known in H. armigera, indicating potential future research directions for alleviating gossypol toxicity in ruminant animals.
Article
Agriculture, Multidisciplinary
Jianyi Li, Long Jin, Yuntong Lv, Yaping Ding, Kunpeng Yan, Hang Zhang, Yiou Pan, Qingli Shang
Summary: This study identifies the important roles of cytochrome P450 genes in detoxification of xenobiotics, particularly cyantraniliprole and gossypol, in Spodoptera litura. Several candidate genes were found to confer tolerance to these substances, while knockdown of certain genes increased mortality. Homology modeling and molecular docking analysis indicate the potential of these genes to bind with cyantraniliprole. Overall, this research provides important insights into the detoxification mechanisms and tolerance of S. litura.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Xinpei Han, Yadi Xing, Yaqian Zhu, Lei Luo, Lulu Liu, Yaohua Zhai, Wenjing Wang, Ruixing Shao, Maozhi Ren, Fuguang Li, Qinghua Yang
Summary: This study analyzed the molecular mechanisms of gossypol biosynthesis regulated by GhMYC2, providing a theoretical basis for cultivating new varieties of low-gossypol or high-gossypol cotton and creating excellent germplasm resources.
Article
Multidisciplinary Sciences
Wei Zhou, Wenxi Wang, Yuxin Liang, Ruibin Jiang, Fensheng Qiu, Xiying Shao, Yang Liu, Le Fang, Maowei Ni, Chenhuan Yu, Yue Zhao, Weijia Huang, Jiong Li, Michael J. Donovan, Lina Wang, Juan Ni, Dachi Wang, Ting Fu, Jianguo Feng, Xiaojia Wang, Weihong Tan, Xiaohong Fang
Summary: The study reveals that the RNA binding protein LRPPRC forms a positive feedback loop with CDK6, and inhibiting LRPPRC overcomes CDK4/6 inhibition resistance. This research uncovers the mechanism of CDK4/6i resistance and provides a novel approach to combine CDK4/6 and LRPPRC inhibitors for cancer therapy.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Wenbin Jiang, Wan Wang, Liangbo Sun, Yunhua Xiao, Teng Ma, Bosheng Li, Xiaojing Yan, Yaran Wu, Hongli Li, Jiqin Lian, Fengtian He
Summary: In this study, we demonstrated for the first time that (-)-Gsp sensitizes EPI to inhibit cell growth and induce apoptosis in hepatocellular carcinoma cells. (-)-Gsp sensitizes EPI by attenuating the EPI-elevated survivin protein levels. Mechanistic studies showed that (-)-Gsp alleviates survivin protein synthesis by suppressing the AKT-4EBP1/p70S6K-survivin and ERK-4EBP1-survivin pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Environmental Sciences
Wei-Kang Wang, Yan-Lu Wang, Wen-Juan Li, Qi-Chao Wu, Sheng-Li Li, Hong-Jian Yang
Summary: The addition of gossypol has a significant detrimental effect on rumen fermentation, especially when the inclusion of gossypol exceeds 0.5 mg/g, and this inhibitory effect is more pronounced in the low-forage group.
Article
Agriculture, Multidisciplinary
Hazna Sartiva, Hisashi Nishiwaki, Koichi Akiyama, Satoshi Yamauchi
Summary: Novel derivatives of E-beta-benzyl-alpha-benzylidene-gamma-butyrolactone with lignano-9,9'-lactone structures were developed as anti-phytopathogenic fungal compounds. The structures and substituents of the compounds were found to have an impact on their activity. The presence of a 2-OCH3 group, a hydrophobic group at the 6-position, and a hydrophobic group of certain size at the 4'-position were necessary for increased activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Polymer Science
Thomas R. Hoye, Mengyuan Jin
Summary: The purpose of this study was to develop a convenient 1H NMR method to estimate the propensity of lactones to participate in ring-opening transesterification polymerization (ROTEP). Methanolysis of 18 lactones was observed in CD3OD solution with sulfuric acid as a catalyst, and the ratio of remaining lactone to ring-opened methyl ester/alcohol could be measured through NMR spectroscopy. The thermodynamic driving force for the methanol ring openings correlated with the extent of ROTEP for different lactone classes, despite different reaction conditions. Qualitative evaluations of the rates of ring-opening methanolysis were also performed, revealing non-obvious relative reactivities. It is recommended to use this simple NMR methanolysis method for evaluating the polymerizability of new lactone monomers in the future.
Article
Chemistry, Multidisciplinary
Sarunpron Khruengsai, Patcharee Pripdeevech, Chutima Tanapichatsakul, Winnie Chemutai Sum, Mahmoud A. A. Ibrahim, Marc Stadler, Sherif S. S. Ebada
Summary: In this study, two new metabolites (1 and 2) and three known compounds were isolated from the submerged cultures of L. chiangraiensis. The chemical structures of the isolated compounds were determined using NMR spectroscopic analyses and HRESIMS, and the absolute configurations of the new compounds were established using TDDFT-ECD spectra. Compound 1 showed significant cytotoxic activities against various cell lines and moderate antibacterial effects.
Article
Neurosciences
Pavlina Mastrandreas, Andreas Arnold, Csaba Boglari, Dominique J-F De Quervain, Attila Stetak, Andreas Papassotiropoulos
Summary: Musashi RNA-binding proteins play a vital role in stem cell maintenance, tumorigenesis, and nervous system development. Inhibiting Musashi activity with a drug improved memory retention and reversed age-related memory decline.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jie Zhang, Ramesh Bista, Takeshi Miyazawa, Adrian T. Keatinge-Clay
Summary: By attenuating the strength of T7 promoter and increasing the concentration of propionate, the productivity of modular polyketide synthases was significantly improved, providing a more efficient approach for the synthesis of designer polyketides and commodity chemicals.
METABOLIC ENGINEERING
(2023)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
