Article
Infectious Diseases
Fabio Bucciol, Elia Maffeis, Emanuela Calcio Gaudino, Laszlo Jicsinszky, Silvia Tagliapietra, Alessandro Barge, Cristina Prandi, Giancarlo Cravotto
Summary: The study focuses on selectively synthesizing active pharmaceutical molecules using microwave irradiation and a specific catalyst, with higher yield achieved under specific starting material.
Review
Chemistry, Multidisciplinary
Yu Gao, Yuzhi Liu, Donglei Zou
Summary: This article reviews the application of microwave irradiation in synthesis and catalytic oxidation, including microwave irradiation alone, microwave with catalysts, microwave-Fenton, microwave-peralcohol, microwave-photochemistry, microwave-electrochemistry, and microwave-sonochemistry. Engineering for upscaling microwave irradiation is also presented.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Ghanshyam Tiwari, Ashish Khanna, Vinay Kumar Mishra, Ram Sagar
Summary: This article provides a comprehensive literature review on the recent developments in the microwave-assisted organic synthesis of N- and O-containing heterocycles, with a specific focus on pyrazolopyrimidines-, coumarin-, quinoline-, and isatin-based scaffolds and their biological activities.
Article
Engineering, Chemical
Chenghong Qiang, Nan Li, Shixiang Zuo, Zhimin Guo, Wei Zhan, Zhengping Li, Jiangquan Ma
Summary: In this study, a novel and efficient RuTe2 cocatalyst was reported for the degradation of diclofenac using a TiO2 photocatalytic heterostructure. The results showed that adding 0.5% RuTe2 to B-TiO2 improved the degradation efficiency by 1.2 times compared to pure B-TiO2. The study also investigated the effects of different preparation conditions on the catalysts.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Marta Maria Gonzalez-Barrios, Marina Tabuyo-Martinez, Vanessa Cascos, Oscar Juan Dura, Jose Antonio Alonso, David Avila-Brande, Jesus Prado-Gonjal
Summary: The combination of microwaves with other classical synthetic methods provides a powerful tool for the preparation of metal oxides and metal chalcogenides. This approach allows for significant modification of reaction kinetics by reducing the processing time to minutes and minimizing energy consumption. Microwave chemistry routes have been used to produce potential thermoelectric compounds such as SnS1-xSex and Zn0.98M0.02O (M = Al, Ga) in just a few minutes. The microwave synthesis method also produces high-quality phases.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Ana Rovisco, Maria Morais, Rita Branquinho, Elvira Fortunato, Rodrigo Martins, Pedro Barquinha
Summary: Contamination of water resources by human activities is a major concern. The photocatalytic process using oxide nanostructures, such as zinc tin oxide (ZTO), shows promising results. ZTO nanoparticles, with their wide band gaps and high surface areas, exhibit high photocatalytic activity, achieving over 90% degradation of rhodamine B in 60 minutes under UV irradiation.
Article
Chemistry, Multidisciplinary
Yahia H. Ahmad, Aymen S. Abu Hatab, Assem T. Mohamed, Mohammed S. Al-Kuwari, Amina S. Aljaber, Siham Y. Al-Qaradawi
Summary: In this study, Mo-TiO2 materials with different Mo contents were synthesized using a microwave-assisted solvothermal approach. The Mo-TiO2 materials exhibited superior adsorption performance and mesoporous structures, showing great potential for various applications.
Article
Materials Science, Ceramics
Raman Mnatsakanyan, Artur Aghoyan, Davit Davtyan
Summary: Boron monoposphide (BP) has unique physical and chemical characteristics, making it suitable for various practical applications. However, the difficult synthesis of the single phase of boron monophosphide limits its usage. Additionally, existing methods for synthesizing nanoscale BP often require high temperatures and long synthesis durations. This paper presents a simple, energy-efficient, and straightforward microwave activation synthesis method, which successfully produces pure single-phase BP nanopowder with a narrow size distribution (70-90 nm) in a short synthesis time (10 min).
CERAMICS INTERNATIONAL
(2023)
Review
Chemistry, Multidisciplinary
Borja Diaz de Grenu, Juan Torres, Javier Garcia-Gonzalez, Sara Munoz-Pina, Ruth de los Reyes, Ana M. Costero, Pedro Amoros, Jose V. Ros-Lis
Summary: This article presents a comprehensive compilation of research results on microwave-assisted synthesis of COFs, covering the synthesis, characteristics, and general issues related to COFs and microwaves. Current and future perspectives on this topic are also discussed.
Article
Chemistry, Organic
Xiang Luo, Qianzhong Zhang, Yi Jiang, Chengxin Wang, Xianheng Song, Jianheng Li, Qinfang Yan, Albert S. C. Chan, Yong Zou
Summary: A copper-catalyzed, ligand-free intramolecular C-N coupling method has been developed for the synthesis of (E)-3-arylideneindolin-2-ones, which are biologically important compounds. This approach offers efficient and practical synthetic route with readily available starting materials and high efficiency.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Eilidh G. Young, Phillip S. Grant, Daniel P. Furkert, Margaret A. Brimble
Summary: Lycibarbarines A-C are spirocyclic alkaloids with a unique tetracyclic framework. The first total syntheses of lycibarbarines A-C were achieved over 10 steps. The spiroketal unit of lycibarbarines A-C exhibits unusually high resistance to acid-mediated isomerization and epimerization.
Article
Chemistry, Physical
Mingliang Guo, Zijian Huang, Binbin Liu, Yanji Bao, Xiaohong Wang, Kexi Zhang, Qiang Wu, Yang Cao, Jinchun Tu, Lei Ding
Summary: The advanced structural design of Ni3S2/NiCo2S4/NF electrodes via a simple microwave-assisted method shows high specific capacitance, remarkable rate capacity, and cycling stability, making them promising anode materials in asymmetric SCs.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Review
Polymer Science
Aarti P. More, Shubham Chapekar
Summary: Hydrogels, crosslinked hydrophilic systems, can be synthesized using various routes, including radiation technology such as gamma, electron beam, and microwave. The optimization of radiation dosage is crucial for achieving desired properties of hydrogels.
Article
Biochemistry & Molecular Biology
Seoyoung Jo, Bohun Kang, Jong-Wha Jung
Summary: This study successfully synthesized bioactive prenylated diresorcinols through microwave-assisted copper catalysis, providing a cost-effective and environmentally friendly method. The highly regioselective prenylation of phenol was achieved, and valuable insights were gained for the preparation of other bioactive prenylated diresorcinols. This synthetic route could be expanded to more complex bioactive compounds.
Article
Biochemistry & Molecular Biology
Marilia R. Oliveira, Juan A. Cecilia, Daniel Ballesteros-Plata, Isabel Barroso-Martin, Pedro Nunez, Antonia Infantes-Molina, Enrique Rodriguez-Castellon
Summary: The global demand for energy and industrial growth has led to a significant increase in the use of fossil fuels. In order to reduce CO2 emissions, this study explores the use of microwave irradiation as an alternative to conventional heating for zeolite A synthesis. The results demonstrate that microwave irradiation can effectively synthesize zeolite A while reducing both temperature and time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zachary J. Hawula, Rohan A. Davis, Daniel F. Wallace, Gautam Rishi, V. Nathan Subramaniam
Summary: Iron is essential for biological processes and its regulation is tightly controlled in the body. This study identified RAD362 compound as an iron chelator and potential therapeutic through screening multiple compounds for their ability to chelate iron.
Article
Biochemistry & Molecular Biology
Daniel J. G. Johnson, Ian D. Jenkins, Cohan Huxley, Mark J. Coster, Kah Yean Lum, Jonathan M. White, Vicky M. Avery, Rohan A. Davis
Summary: A radical approach using photoredox and Diversinate((TM)) chemistry on the OSM triazolopyrazine scaffold led to the synthesis of 12 new analogues, which were tested for antimalarial activity and cytotoxicity. Some compounds showed moderate antimalarial activity with no toxicity against HEK293 cells.
Article
Microbiology
Ian Tietjen, Joel Cassel, Emery T. Register, Xiang Yang Zhou, Troy E. Messick, Frederick Keeney, Lily D. Lu, Karren D. Beattie, Topul Rali, Pablo Tebas, Hildegund C. J. Ertl, Joseph M. Salvino, Rohan A. Davis, Luis J. Montaner
Summary: The study identified (-)-hopeaphenol as a potent inhibitor of SARS-CoV-2 cell entry and replication, showing activity against different variants of the virus. This compound has potential as an antiviral agent in combating the COVID-19 pandemic.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Plant Sciences
Sasha Hayes, Aya C. Taki, Kah Yean Lum, Joseph J. Byrne, Jonathan M. White, Merrick G. Ekins, Robin B. Gasser, Rohan A. Davis
Summary: This study identified a marine extract derived from an Australian sponge with activity against an economically important parasitic nematode. Further analysis led to the purification of four known sesterterpenes and the revision of their chemical structures. The findings suggest that these sesterterpenes deserve further investigation for their activity against nematodes.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Organic
Sasha Hayes, Aya C. Taki, Kah Yean Lum, Joseph J. Byrne, Merrick G. Ekins, Robin B. Gasser, Rohan A. Davis
Summary: In this study, chemical investigations on an Australian marine sponge led to the discovery of a new alkaloid. Evaluation of this compound and other marine bromotyrosine alkaloids revealed their potential nematocidal activity against a harmful parasite.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Kah Yean Lum, Jonathan M. White, Daniel J. G. Johnson, Vicky M. Avery, Rohan A. Davis
Summary: Nine new fluorinated analogues were synthesised using late-stage functionalisation on the Open Source Malaria (OSM) triazolopyrazine scaffold. The structures of all analogues were characterised and their inhibitory activity against Plasmodium falciparum and cytotoxicity against a human embryonic kidney cell line were tested. Some compounds showed moderate antimalarial activity, while none displayed cytotoxicity at high concentrations. Substitution of CF3 and CF2H moieties at the C-8 position significantly reduced antimalarial activity, while incorporation of a CF2Me group completely abolished the effect.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Chen Zhang, Kah Yean Lum, Aya C. Taki, Robin B. Gasser, Joseph J. Byrne, Luis J. Montaner, Ian Tietjen, Vicky M. Avery, Rohan A. Davis
Summary: The study focused on the purification and synthesis of a bioactive compound derived from Eremophila microtheca. A library of carbamate-based compounds was generated using the synthesized compound as a scaffold, and their activities against parasites, malaria, and HIV were evaluated. The results showed promising antiparasitic, antimalarial, and antiviral activities of certain compounds.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Medicinal
Folake A. Egbewande, Brett D. Schwartz, Sandra Duffy, Vicky M. Avery, Rohan A. Davis
Summary: The incorporation of bromine, iodine or fluorine into the tricyclic core structure of thiaplakortone A (1), a potent antimalarial marine natural product, was achieved. Although yields were low, a small library of thiaplakortone A analogues (3-11) was synthesised using a Boc-protected thiaplakortone A (2) as a scaffold for late-stage functionalisation. The antimalarial activity of the new analogues was evaluated, with the mono-brominated analogue (compound 5) showing the best activity against both drug-sensitive and drug-resistant strains of Plasmodium falciparum.
Article
Oncology
Alanah Varricchio, Sidra Khan, Zoe K. Price, Rohan A. Davis, Sunita A. Ramesh, Andrea J. Yool
Summary: Glioblastoma is a highly lethal brain tumor with invasive spreading capabilities. This study found that blocking glutamate receptors and aquaporin-1 channels can limit the motility of tumor cells without causing harm to normal brain cells. Using combination therapy can focus the effects on cancer cells while minimizing off-target effects.
Article
Biotechnology & Applied Microbiology
Rohan A. Davis, Gunnar Cervin, Karren D. Beattie, Topul Rali, Marilyne Fauchon, Claire Hellio, Lovisa Bodin Akerlund, Henrik Pavia, Johan Svenson
Summary: This study investigates the antifouling potential of polyphenolic resveratrol multimers isolated from two Anisoptera species found in the Papua New Guinean rainforest. The compounds showed inhibitory effects on marine microfoulers and barnacle cyprids, with (-)-hopeaphenol demonstrating strong inhibitory effects against both microalgal and bacterial adhesion. Resveratrol displayed lower antifouling activity and higher toxicity against MCR-5 fibroblasts. This study highlights the potential of natural products as a valuable source for the discovery of novel antifouling agents with low toxicity.
Article
Biochemistry & Molecular Biology
Simon H. Apte, Penny L. Groves, Maxine E. Tan, Viviana P. Lutzky, Tharushi de Silva, Joshua N. Monteith, Stephanie T. Yerkovich, Brendan J. O'Sullivan, Rohan A. Davis, Daniel C. Chambers
Summary: Idiopathic pulmonary fibrosis is a common and deadly lung disease with unknown cause. Recent advances in genomic research have identified potential therapeutic compounds for lung fibrosis, including a compound isolated from an Australian rainforest plant with antifibrotic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tam M. T. Tran, Russell S. Addison, Rohan A. Davis, Bernd H. A. Rehm
Summary: The sponge-derived natural products ianthelliformisamines A-C can work synergistically with ciprofloxacin to reduce the minimum inhibitory concentration (MIC) of Pseudomonas aeruginosa biofilms. Ianthelliformisamine C exhibits bactericidal effects on both free-living and biofilm populations of various strains, including the clinically relevant mucoid variant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anthony R. Carroll, Brent R. Copp, Rohan A. Davis, Robert A. Keyzers, Michele R. Prinsep
Summary: This review covers the literature on marine natural products (MNPs) published in 2020, with 757 citations referring to compounds isolated from a variety of marine organisms. The emphasis is on new compounds, their biological activities, source organisms, and country of origin. The review also includes relevant reviews, biosynthetic studies, and syntheses that led to structural revisions, as well as a meta analysis of bioactivity data on new MNPs reported in the past five years.
NATURAL PRODUCT REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Anthony R. Carroll, Brent R. Copp, Rohan A. Davis, Robert A. Keyzers, Michele R. Prinsep
Summary: This review summarizes the literature on marine natural products (MNPs) published in 2020, covering a wide range of compounds isolated from various marine organisms. The focus is on new compounds discovered in 2020, including their biological activities, source organisms, and country of origin. The review also includes a meta analysis of bioactivity data for new MNPs reported in the past five years.
NATURAL PRODUCT REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Anthony R. Carroll, Brent R. Copp, Rohan A. Davis, Robert A. Keyzers, Michele R. Prinsep
Summary: This review summarizes the literature on marine natural products (MNPs) published in 2019, covering a wide range of organisms and compounds, with a focus on new compounds and their biological activities and country of origin. Methods for studying marine fungi and their chemical diversity are also discussed.
NATURAL PRODUCT REPORTS
(2021)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
