期刊
TETRAHEDRON LETTERS
卷 50, 期 8, 页码 886-889出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.12.029
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资金
- UK EPSRC Crime Prevention and Detection Programme [GR/S64134/01]
- RCUK Basic Technologies Programme [GR/S79268/01]
- Wellcome Trust
- BBSRC [BBS/E/J/000C0618] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000C0618] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [GR/S64134/01, GR/S79268/01] Funding Source: researchfish
Mannose-coated CdS quantum dots (Man-QDs) were prepared in a facile aqueous, one-pot process that exploits the self-assembly of thiolated mannose in the presence of CdS under reducing conditions. The resulting similar to 15 nm diameter nanoparticles produce an intense, broad luminescence emission centred at 550 nm. These Man-QDs induce luminescent aggregates of Escherichia coli which can be used to detect bacteria in cell suspensions containing as few as 10(4) E. coli per mL. The aggregation process is dependent on the E coli cell surface FimH mannose-specific lectin. The recognition and subsequent detection of the E. coli using the Man-QD has been shown to be specific as aggregation does not occur either with an E. coli strain defective in the FimH lectin or with galactose-coated QDs. (C) 2008 Elsevier Ltd. All rights reserved.
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