Article
Chemistry, Multidisciplinary
Mustafa Oguzhan Kaya, Tuna Demirci, Umit Calisir, Oguzhan Ozdemir, Yesim Kaya, Mustafa Arslan
Summary: This study investigated the activation of pyruvate kinase enzyme in vitro by different urea substituents in 1,4-dihydropyridine derivatives synthesized via the Hantzsch reaction method. The synthesized compounds successfully activated pyruvate kinase, with the compound ethyl-4-(4-(4-(3-(3-methoxyphenyl)thioureido)phenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,7,8-hexahydroquinolin-3(7)) showing the strongest activation effect.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Multidisciplinary Sciences
Hossein Ghafuri, Zeinab Tajik, Nastaran Ghanbari, Peyman Hanifehnejad
Summary: A novel g-C3N4@l-arginine nanocatalyst was synthesized and evaluated for its thermal stability, easy separation, and performance in the synthesis of various derivatives. The nanocatalyst showed promising results for multicomponent reactions and reusability.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Santosh T. Shinde, Kaluram G. Kanade, Ramesh B. Gawade, Vikram B. Hinge, Manish D. Shinde, Digambar B. Bankar, Nitin M. Thorat, Dinesh P. Amalnerkar
Summary: AlCl3-loaded ZnO nanoparticles were used as an efficient catalyst for 1,4-dihydropyridine synthesis under ambient temperature and solvent-free conditions. The nanoparticles were synthesized by precipitation and the catalyst was prepared by loading AlCl3 on ZnO nanoparticles. The catalyst showed high efficiency with a 92% yield for the synthesis of 1,4-dihydropyridine.
Article
Chemistry, Organic
Sungmin Kang, Taek Hyeon Kim
Summary: An isothiouronium organocatalyst prepared from thiourea was first employed to catalyze the transfer hydrogenation of various 2-alkyl and arylquinolines efficiently. Good to excellent yields of tetrahydroquinolines were obtained under mild conditions with a small amount of catalyst (5 mol%).
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Physical
Arzoo Chauhan, Ashish Kumar Kar, Rajendra Srivastava
Summary: The effective dissociation of biomass-derived formic acid in water for the hydrogenation of levulinic acid and quinoline was investigated using Ru decorated carbon nanoflakes as catalysts. The catalyst showed outstanding activity and selectivity, with high conversion and selectivity achieved for both levulinic acid and quinoline. The study provides insights into the use of formic acid as a sustainable hydrogen source and the development of metal decorated N-doped carbons for catalytic hydrogenation reactions.
APPLIED CATALYSIS A-GENERAL
(2022)
Article
Environmental Sciences
Akansha Agrwal, Anil Verma, Neelam Chantola, Shivani Verma, Virendra Kasana
Summary: In this study, 22 derivatives of dihydropyridine (DHP) were synthesized using Boric acid catalyst in solventless conditions. The synthesis was confirmed by FTIR analysis, 1HNMR, and 13CNMR analysis. Quantitative structure-activity relationship analysis was performed using an artificial neural network and comparative molecular field analysis. Docking experiments showed favorable interaction between synthesized DHP derivatives and protein receptors with significant binding energy values. The synthesized derivatives exhibited good to moderate pre-emergence and post-emergence herbicidal activity. Therefore, substituted DHP derivatives may have potential as herbicides.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2022)
Article
Chemistry, Physical
Prithwish Ghosh, Na Yeon Kwon, Youjung Byun, Neeraj Kumar Mishra, Jung Su Park, In Su Kim
Summary: In this study, a cobalt(II)-catalyzed method for C-H alkylation and acylation of N-heterocycles using 1,4-dihydropyridines (DHPs) as alkylating and acylating agents was reported. The combination of KBrO3 and a Co(II) catalyst successfully generated alkyl and acyl radicals from DHPs. This method was applicable to various heterocycles and demonstrated selectivity in modifying drug candidates and synthesizing bioactive molecules on a gram scale.
Review
Chemistry, Organic
Keshav Kumar Saini, Rupal Rani, Bhupinder Muskan, Neena Khanna, Bhupinder Mehta, Rakesh Kumar
Summary: 1,4-Dihydropyridine is an important class of nitrogen-containing heterocyclic compounds with significant therapeutic effects in pharmaceutical chemistry. Multicomponent reactions have been discovered as valuable tools for the synthesis of 1,4-dihydropyridine. The efficient synthesis of 1,4-dihydropyridine via multicomponent reactions provides structural diversity crucial for the discovery of new compounds and therapeutics. This review focuses on the recent developments in the multicomponent synthesis of 1,4-dihydropyridines and their fused analogs as potent antihypertensive drugs, offering valuable insights for researchers in heterocyclic chemistry, medicinal chemistry, and drug design.
CURRENT ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mohammad T. Jafari-Chermahini, Hossein Tavakol
Summary: The study investigated the catalytic activity of various spinel iron oxide nanoparticles in Hantzsch reaction, with HgFe2O4 showing the highest activity. The structural properties of synthesized 1,4-dihydropyridine were characterized, and in silico molecular simulations confirmed their promising calcium channel blocking ability against various TRPV6 proteins.
Article
Chemistry, Organic
Gottam Sreenivasulu, Chittala Emmaniel Raju, Manda Shareni Palaci, Balasubramanian Sridhar, Galla Karunakar
Summary: An efficient synthetic method was developed to obtain isoquinoline-derived diene esters through an atom-economic process using enynones and isoquinoline-N-oxides. The reaction involved [3 + 2]-cycloaddition, isoxazole ring opening, and [1,5]-sigmatropic rearrangement, resulting in the formation of one C-C and two C-O bonds. Additionally, quinolin-2(1H)-ylidene-substituted 1,5-diones were successfully synthesized from enynones and quinoline-N-oxides with high yields.
Article
Chemistry, Physical
Maofu Pang, Le-Le Shi, Yufang Xie, Tianyi Geng, Lan Liu, Rong-Zhen Liao, Chen-Ho Tung, Wenguang Wang
Summary: Selective transfer hydrogenation of pyridines to N-H 1,4-dihydropyridines has been achieved by cobalt-amido cooperative catalysis using H3NmiddotBH3 as a dihydrogen source. The reactions exhibit high chemo- and regioselectivity under mild conditions, providing a practical method to regenerate Hantzsch analogues after H2 delivery.
Article
Chemistry, Organic
M. Shaibuna, K. Sreekumar
Summary: Deep eutectic solvents, formed from two or more components, demonstrate dual roles as catalyst and reaction medium for the synthesis of dihydropyridine derivatives. Among six DESs studied, DES 2 (ZrOCl2.8H(2)O and ethylene glycol at 1:2 ratio) was found to be the most effective catalyst with excellent recyclability. The major advantages of DESs in this reaction include easy preparation, low cost, non-volatility, biodegradability, simple catalytic process, excellent conversion, and reusability.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Jayashree Ethiraj, Ranjith Sekar, Bhaskaran Shankar, Moola Joghee Nanjan, R. K. Sankaranarayanan, Khanh B. Vu
Summary: In this study, single crystal structure solution and refinement were conducted on two 1,4-dihydropyridine derivative molecules. Hirshfeld surface analysis, DFT calculations, and NBO analysis were performed to investigate the chemical features, intermolecular interactions, and molecular properties of these molecules. These findings contribute to the understanding of the structure and properties of these molecules.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Guang-Bin Shen, Bao-Chen Qian, Xiao-Qing Zhu, Yan-Hua Fu
Summary: In this study, the pKa values of 69 polar alkanes in acetonitrile were calculated, and unexpected reduction and antioxidant properties were discovered in some of these compounds. Unlike common hydrogen molecule reductants, polar alkanes release protons first and then hydrides. This difference in acidity results in their behavioral and thermodynamic differences.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Yanfeng Ma, Tianci Xu, Fuhong Xiao, Guojiang Mao, Guo-Jun Deng
Summary: In this study, a metal-free multicomponent condensation sequence, [2 + 2 + 1 + 1], has been reported for the synthesis of polysubstituted pyridines. The starting materials are readily available and the reaction conditions are simple. This cyclization reaction exhibits good selectivity and yields various pyridines with a broad range of functional groups.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Biochemistry & Molecular Biology
Jebiti Haribabu, Kumaramangalam Jeyalakshmi, Yuvaraj Arun, Nattamai S. P. Bhuvanesh, Paramasivan Thirumalai Perumal, Ramasamy Karvembu
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2017)
Article
Polymer Science
Sita Lakshmi Thyagarajan, Giriprasath Ramanathan, Sivakumar Singaravelu, S. Kandhasamy, P. T. Perumal, Uma Tiruchirapalli Sivagnanam
Article
Chemistry, Medicinal
Chandrasekar Balachandran, Veeramuthu Duraipandiyan, Yuvaraj Arun, Balachandran Sangeetha, Nobuhiko Emi, Naif Abdullah Al-Dhabi, Savarimuthu Ignacimuthu, Yoko Inaguma, Akinao Okamoto, Paramasivan T. Perumal
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2016)
Article
Materials Science, Biomaterials
Giriprasath Ramanathan, Sivakumar Singaravelu, Thangavelu Muthukumar, Sitalakshmi Thyagarajan, Hanumant Singh Rathore, Uma Tiruchirapalli Sivagnanam, Paramasivan Thirumalai Perumal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2017)
Review
Materials Science, Biomaterials
Subramani Kandhasamy, Giriprasath Ramanathan, Thangavelu Muthukumar, SitaLakshmi Thyagarajan, Narayanan Umamaheshwari, V. P. Santhanakrishnan, Uma Tiruchirapalli Sivagnanam, Paramasivan Thirumalai Perumal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Materials Science, Biomaterials
Giriprasath Ramanathan, Sivakumar Singaravelu, Thangavelu Muthukumar, Sitalakshmi Thyagarajan, Paramasivan Thirumalai Perumal, Uma Tiruchirapalli Sivagnanam
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Materials Science, Biomaterials
Giriprasath Ramanathan, Sivakumar Singaravelu, Thangavelu Muthukumar, Sitalakshmi Thyagarajan, Hanumant Singh Rathore, Uma Tiruchirapalli Sivagnanam, Paramasivan Thirumalai Perumal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2017)
Article
Polymer Science
Kumaravel Elavarasan, Chinnusamy Saravanan, Nagarajan Panneer Selvam, Yen-Ju Hsieh, Yi-Min Chang, Leeyih Wang
POLYMER INTERNATIONAL
(2018)
Article
Chemistry, Multidisciplinary
Kumaravel Elavarasan, Chinnusamy Saravanan, Nagarajan Paneer Selvam, Shanmugam Easwaramoorthi
Article
Chemistry, Organic
Khadhar Navaz Umar Basha, Shanthi Gnanamani
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2019)
Article
Chemistry, Organic
Khadhar Navaz Umar Basha, Shanthi Gnanamani, Prakash Shanmugam, Sujatha Venugopal, Sangeetha Murthy, Balagurunathan Ramasamy
Summary: The study presents a simple and convenient one-pot synthesis method for the preparation of 3-(1H-indole-3-carbonyl)-2H-chromen-2-one derivatives with high yields and wide substrate scope. The synthesized compounds exhibit good radical scavenging ability, reducing power, as well as antibacterial and antifungal activities, showing potential for various applications.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Kanagaraj Naveen, Savariyappan Albert Nikson, Paramasivan Thirumalai Perumal
ADVANCED SYNTHESIS & CATALYSIS
(2017)
Article
Nanoscience & Nanotechnology
Subramani Kandhasamy, Sathiamurthi Perumal, Balaraman Madhan, Narayanan Umamaheswari, Javid Ahmad Banday, Paramasivan Thirumalai Perumal, Vichangal Pridiuldi Santhanakrishnan
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Chemistry, Multidisciplinary
J. C. Jeyaveeran, Chandrasekar Praveen, Y. Arun, A. A. M. Prince, P. T. Perumal
JOURNAL OF CHEMICAL SCIENCES
(2016)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
