期刊
TETRAHEDRON LETTERS
卷 50, 期 19, 页码 2252-2255出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.210
关键词
Dihydropyrano[2,3-c]pyrazole; Pyrazole; Dihydropyrane; Cinchona alkaloid; Organocatalysis; Multi-component reaction; Tandem reaction
资金
- Welch Foundation [AX-1593]
- National Institute of General Medical Sciences [1SC1GM082718-01A1]
The first enantioselective synthesis of biologically active 6-amino-5-cyanodihydropyrano[2,3-c]pyrazoles has been achieved through a cinchona alkaloid-catalyzed tandem Michael addition and Thorpe-Ziegler type reaction between 2-pyrazolin-5-ones and benzylidenemalononitriles. The reaction may also be carried out in a three-component or a four-component fashion via the in situ formation of these two components from simple and readily available starting materials. The desired products were obtained in excellent yields with mediocre to excellent enantioselectivities (up to >99% ee). (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据