Article
Chemistry, Applied
Fulin Chen, Chuanle Zhu, Huanfeng Jiang
Summary: The synthesis of benzoxazoles using inorganic hydroxylamine hydrochloride as the nitrogen source in a [3+1+1] annulation reaction with benzo-1,2-quinones and aldehydes was reported, resulting in high yields of various useful benzoxazoles. Preliminary mechanistic studies indicated that the quinone oxime serves as the reaction intermediate instead of the aldehyde oxime.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Jianyi Shi, Zheng Zeng, Shengting Xu, Zechun Cai, Yuehua Luo, Yongbo Fan, Zhongzhi Zhu, Tingting Wen, Xiuwen Chen
Summary: In this study, a method for forming C(sp3)-C(sp2) bonds via copper catalyst-promoted cross coupling was developed. The reaction involved the sequential functionalization of the N1, C3, and C1 positions of 3-haloisoquinoline, resulting in the formation of new C-N, C=O, and C-C bonds. This method enables the efficient synthesis of 1,2-disubstituted isoquinolinones.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Physical
Sidi Cheng, Yu Luo, Ting Yu, Jing Li, Chunfang Gan, Shuang Luo, Qiang Zhu
Summary: An unactivated alkene was successfully subjected to 1,2-difunctionalization through a palladium-catalyzed four-component cascade reaction, leading to the convenient synthesis of acetamides with various substituents and pyrrolo-fused heterocycles.
Article
Chemistry, Multidisciplinary
H. Tao
Summary: A series of -N-Methylspiro[2 ',11 '']indeno[1,2-b]quinoxalinespiro[3 ',2]-6-arylmethylenecyclohexanone-4 '-arylpyrrolidine compounds were synthesized by a catalyst-free one-pot two-step four-component [3+2] cycloaddition reaction. The structures of these products were characterized using a combination of NMR, IR, ESI-HRMS, and X-ray data.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Masoud Mohammadi Vala, Mohammad Bayat, Yadollah Bayat
Summary: This method offers a simple and efficient approach for the synthesis of dihydro-8H-acenaphtho[1',2':4,5]pyrrolo[1,2-a]imidazole-diol derivatives through a one-pot, four-component reaction. The reactions are conducted in ethanol at reflux without the need for a catalyst, resulting in good to high yields with experimental simplicity and easy purification.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Organic
Guodong Yin, Yuan Li, Ling Fan
Summary: Zirconium tetrachloride was used as a catalyst to synthesize two fused-ring compounds, confirmed by H-1 NMR, C-13 NMR, IR, HRMS and X-ray single crystal diffraction analysis. The method provides a complementary approach to enriching the library of corresponding heterocyclic compounds due to its mild reaction conditions and easily available starting materials.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhentao Pan, Shuaijun Shi, Xuancheng Yang, Xuqiong Xiao, Wangqin Zhang, Shiliang Wang, Yongmin Ma
Summary: An unprecedented eco-friendly multi-component domino synthesis approach was used to produce novel organic compounds. The process is simple, yields high purity products, has a simple work-up procedure, and meets the requirements of green synthesis.
Article
Chemistry, Organic
Jiang-Song Zhai, Da-Ming Du
Summary: A bifunctional thiourea-catalyzed asymmetric [3 + 2] annulation reaction has been developed to synthesize chiral dispiro[indene-pyrrolidine-pyrimidine] compounds from 2-isothiocyanato-1-indanones and barbiturate-based olefins. The reaction has shown excellent yields and stereoselectivities. The synthetic utility of the products has been demonstrated through gram-scale synthesis, one-pot three-component reactions, and further transformation experiments.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Milad Bazaz Rastkar, Bita Mohtat, Gholam Bagheri Marandi, Hoorieh Djahaniani
Summary: In this study, a total of eighteen derivatives of N-((5-(aryl)-4H-pyrazol-3-yl)(aryl)methyl)benzo[d]thiazol-2-amine were synthesized via a one-pot method, with confirmation done through various analytical techniques.
Article
Chemistry, Physical
Arul Murugesan, Thishana Singh, Ramar Rajamanikandan, Madhan Vinu, Malaichamy Ilanchelian, Chia-Her Lin, Robert Moonsamy Gengan
Summary: A novel compound was synthesized and characterized using various spectroscopic and computational methods, with a focus on reactive sites and biological activity. The compound showed potential biological activity based on molecular docking studies and emission spectral data analysis.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Organic
Hui Xu, Guan-Wu Wang
Summary: We have developed a novel solvent-free ball-milling reaction method for the synthesis of polysubstituted 1,2-dihydroquinolines in moderate to excellent yields. This method features mild reaction conditions, short reaction time, and is applicable for large-scale synthesis, providing a facile and practical alternative for the synthesis of 1,2-dihydroquinoline compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Mario Ordonez, Ruben Oswaldo Arguello-Velasco, Teodoro Miranda-Blancas, Ivan Romero-Estudillo, Victoria Labastida-Galvan
Summary: This study presents a practical method for synthesizing four diethyl and ethyl phosphonate compounds. The method involves regioselective 1,4-phosphonylation and highly diastereoselective reduction, followed by a Mitsunobu reaction to obtain the desired products.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Physical
Youness El Bakri, Malahat Kurbanova, Sabir Ali Siddique, Subramani Karthikeyan, Abel Maharramov, Nacaf Ramazanzade
Summary: The three-component condensation reaction of 4-methoxybenzaldehyde with acetophenone and urea in the presence of CF3COOH resulted in the synthesis of 6-(4-methoxyphenyl)-4-phenyl-1,2-dihydropyrimidine-2-one, which was confirmed by X-ray analysis. Computational studies using DFT and TD-DFT were carried out to analyze the spectral data and electronic parameters, which corroborated well with the experimental results. The findings suggest that the synthesized compound has enhanced non-linear optical properties and is a stable and promising drug candidate, as supported by molecular docking studies and ADMET parameter analysis.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Xiangkai Ji, Jing Li, Prem Prakash Sharma, Xiangyi Jiang, Brijesh Rathi, Zhen Gao, Lide Hu, Dongwei Kang, Erik De Clercq, Simon Cocklin, Chuanfeng Liu, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Summary: This study investigated the inhibitory activity of phenylalanine derivatives against HIV. The results showed that compound I-19 exhibited the best anti-HIV-1 activity, while compound I-14 displayed excellent HIV-2 inhibitory activity. Additionally, the binding ability of these compounds to HIV was confirmed. These findings contribute to the discovery of effective anti-HIV drugs.
Article
Chemistry, Physical
Zhi-Peng Bao, Youcan Zhang, Xiao-Feng Wu
Summary: In this study, a palladium-catalyzed four-component difluoroalkylative carbonylation reaction was developed, leading to the synthesis of a variety of β-difluoromethylene substituted amide derivatives with high yields. Ethylene gas can also be transformed into the corresponding products, and this reaction can be applied to the synthesis of various natural products or bioactive molecules.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
