期刊
TETRAHEDRON LETTERS
卷 50, 期 13, 页码 1498-1500出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.01.075
关键词
DPA; Oxidative stress; Neuroprostane; Total synthesis; Wittig; HWE
The first synthesis of 4-F-3t-Neuroprostane 1a and its 4-epimer is described. This molecule presents an important contribution to the study of neuronal oxidative stress in DHA-omega 3 depleted brain. The key step involves the introduction of two unsaturated side chains into the chiral polyfunctional cyclopentane 4 via E selective HWE reaction and Z selective Wittig olefination for alpha and omega chains, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
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