Article
Chemistry, Multidisciplinary
Zhong-Yu Ruan, Yong-Fang Lu, Xi Lv, Jian-Zhong Wu, Yong-Cong Ou, Yue-Peng Cai
Summary: A zero-dimensional dinuclear europium complex with strong Eu(iii) red photoluminescence was constructed via hydrolysis of benzonitrile to benzoate. This complex serves as a convenient luminescent sensor for clinafloxacin with a detection limit of 0.21 μM.
Article
Infectious Diseases
Bela Kocsis, Daniel Gulyas, Dora Szabo
Summary: Novel antimicrobial agents such as delafloxacin, finafloxacin, and zabofloxacin have been recently approved for clinical use, showing broad-spectrum antibacterial activity against various infections. Despite their efficacy, reports of delafloxacin resistance emphasize the importance of cautious antibiotic use.
Article
Microbiology
M. Gill Hartley, Isobel H. Norville, Mark I. Richards, Kay B. Barnes, Kevin R. Bewley, Julia Vipond, Emma Rayner, Andreas Vente, Stuart J. Armstrong, Sarah V. Harding
Summary: Finafloxacin demonstrates optimal antibacterial activity in low pH environments, offering a therapeutic advantage over traditional antibiotics in treating bacterial infections associated with acidic foci. However, it does not reduce the level of bacterial colonization in tissues compared to doxycycline or ciprofloxacin. Despite this, treatment with finafloxacin shows a reduction in tissue damage associated with C. burnetii infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kyungmin Huh, Minsun Kang, Jaehun Jung
Summary: There was no significant difference in the risk of aortic aneurysm and aortic dissection (AA/AD) between patients who were administered oral fluoroquinolone (FQ) and those who were administered third-generation cephalosporins (3GC). The study findings suggest that the use of FQ should not be deterred when clinically indicated.
EUROPEAN HEART JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Zhipeng Wang, Stephen F. Martin
Summary: In this study, we designed, synthesized, and evaluated two novel photocages based on the o-nitrobenzyl chemotype and carbazole ring system. The photochemical properties and decaging efficiencies of these new photocages were investigated and compared to the existing nitrodibenzofuran (NDBF) cage. The results showed that one of the new photocages exhibited significantly higher decaging efficiency than the NDBF cage. Additionally, the water solubility of one of the photocages was improved through modification, which is important for applications in aqueous conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Engineering, Environmental
Dingxiang Wang, Zhen Zeng, Honglong Zhang, Jing Zhang, Ruopeng Bai
Summary: The study found that the reaction rate of Fe(VI) with fluoroquinolone antibiotics is strongly dependent on pH, reaching its maximum at around pH 6.5. In alkaline solution, high-valent iron species were identified as the major reactive species, while hydroxyl radicals were generated through Fenton or Fenton-like processes in acidic conditions with limited contribution.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Environmental Sciences
Wenlong Liao, Li Zheng, Juan Hao, Lijuan Huang, Qinghui Wang, Zhihang Yin, Ting Qi, Lingpu Jia, Kunping Liu
Summary: A multifunctional magnetic plasmonic photocatalyst was prepared through a green and efficient process. It consisted of magnetic mesoporous anatase titanium dioxide (Fe3O4@mTiO2), Ag nanoparticles (Ag NPs), and graphene oxide (GO). The catalyst showed adsorption, surface-enhanced Raman spectroscopy (SERS) monitoring, and photodegradation capabilities for fluoroquinolone antibiotics (FQs). The catalyst exhibited improved degradation rates and recyclability compared to other materials, making it a potential solution for the removal and monitoring of residual FQs in environmental water.
Article
Environmental Sciences
Kafilat A. Bawa-Allah, Aideloje O. Ehimiyein
Summary: In this study, the ecotoxicological effects of human and veterinary antibiotics on D. magna were assessed. The results showed that the veterinary fluoroquinolone antibiotic enrofloxacin was the most toxic to D. magna and posed a moderate risk to the species in surface waters and wastewaters.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Environmental Sciences
Bo Zhang, Juan Chen, Chao Wang, Peifang Wang, Ge Cui, Jingjing Zhang, Yu Hu, Han Gao
Summary: This study investigated the adsorption behavior of two fluoroquinolone antibiotics on different aggregation fractions separated from the sediment of Taihu Lake. The results showed that the adsorption of both antibiotics fitted the Freundlich model, regardless of sediment aggregation size. The adsorption of the antibiotics was dependent on the size of sediment aggregation fractions, with macroaggregation exhibiting the strongest capacity. The adsorption mechanism involved a combination of chemical and physical adsorptions, with chemical adsorption being the dominant process.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Yu Xia, Qin-Ming Xie, Ta-Jen Chu
Summary: This paper studied the effects of two fluoroquinolone antibiotics on Microcystis aeruginosa and found that these antibiotics inhibit the growth of Microcystis aeruginosa and increase its toxin production capacity. This is of great significance for the ecological risk assessment of antibiotics in the water environment.
Article
Engineering, Environmental
Chen-Yu Zhao, Shaoguo Ru, Pengfei Cui, Xin Qi, Mayur B. Kurade, Swapnil M. Patil, Byong-Hun Jeon, Jiu-Qiang Xiong
Summary: This study investigated the ecotoxicological effects, biodegradation, and multiple metabolic pathways of enrofloxacin (ENR) by ryegrass, identifying key metabolic genes and proposing a biodegradation pathway. Results showed high removal rates of ENR by biodegradation and revealed the key functional genes involved in the degradation process. This study contributes to the understanding of antibiotic biodegradation in plants and highlights the potential of ryegrass in treating ENR-polluted water.
Article
Engineering, Multidisciplinary
Siyasanga Mpelane, Nomvano Mketo, Ndzondelelo Bingwa, Philiswa Nosizo Nomngongo
Summary: The adsorptive removal of levofloxacin from aqueous solutions was found to be exothermic and spontaneous, as indicated by the thermodynamics parameters.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Engineering, Chemical
Zhihuang Fang, Shirong Zhao, Gang Xue, Xiaonuan Wang, Peizhe Sun, Yang Yu, Zilin Zhou, Qi Wang, Yajie Qian
Summary: N-modified sludge-derived biochar (N-SDBC) was prepared and used for the activation of peroxydisulfate (PDS) to degrade fluoroquinolone antibiotics (FQs). Seven commonly used FQs were effectively degraded by N-SDBC/PDS, and the dominant reactive species were identified as O-1(2), while SO4 center dot- and (OH)-O-center dot played minor roles. Graphite-N and Fe-0 on the surface of N-SDBC were identified as the main active sites for PDS activation. The application in surface water and wastewater samples demonstrated the efficiency of N-SDBC/PDS for FQs removal.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Environmental
Sama M. Al-Jubouri, Haider A. Al-Jendeel, Sarmad A. Rashid, Sirhan Al-Batty
Summary: In this study, the efficient adsorption capacity of eco-friendly ZSM-5 nanocrystals-carbon composite (NZC) for ciprofloxacin antibiotics was investigated. The results showed that NZC exhibited outstanding adsorption performance for ciprofloxacin antibiotics, making it a highly efficient adsorbent for the removal of ciprofloxacin-loaded effluents.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
M. Ganeshbabu, J. Shiva Priya, G. Murali Manoj, N. Prasanna Naga Puneeth, C. Shobana, H. Shankar, R. Kalai Selvan
Summary: Research demonstrates the efficient degradation of fluoroquinolone-based antibiotics using functionalized copper oxide nanoparticles as a photocatalyst, highlighting their high efficiency and stability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Medicinal
Debasis Das, Papiya Sikdar, Moumita Bairagi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Review
Chemistry, Medicinal
Debasis Das, Mayank Pandya
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2018)
Review
Biochemistry & Molecular Biology
Debasis Das, Jian Hong, Shu-Hui Chen, Guangyi Wang, Leonid Beigelman, Scott D. Seiwert, Brad O. Buckman
BIOORGANIC & MEDICINAL CHEMISTRY
(2011)
Article
Chemistry, Organic
Jian Hong, Xin Xu, Debasis Das, Pengyu Yang, Shu-Hui Chen, Ge Li
LETTERS IN ORGANIC CHEMISTRY
(2010)
Article
Chemistry, Medicinal
Debasis Das, Lingzhi Xie, Jingbing Wang, Xin Xu, Zonghua Zhang, Jingli Shi, Xiaoyong Le, Jian Hong
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Review
Chemistry, Medicinal
Debasis Das, Jian Hong
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Debasis Das, Jingbing Wang, Yong Li, Jingli Shi, Jian Hong
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Review
Chemistry, Medicinal
Debasis Das, Jian Hong
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Debasis Das, Lingzhi Xie, Jingbing Wang, Jingli Shi, Jian Hong
BIOORGANIC CHEMISTRY
(2020)
Review
Chemistry, Medicinal
Md Nasim Khan, Digvijaysinh K. Parmar, Debasis Das
Summary: Azo compounds are widely used in various industries and play important roles in medicinal chemistry, such as antibacterial, antifungal, and antioxidant. However, their application in medicinal chemistry is limited by safety concerns related to metabolic degradation.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Debasis Das, Jingbing Wang, Jian Hong
Summary: Lung cancer is a major cause of global mortality, with mutations in regulatory genes and irregular signal transduction pathways observed in non-small cell lung cancer patients. Several kinases have been identified as targetable biomarkers, leading to the FDA approval of multiple kinase inhibitors for NSCLC treatment.
Article
Biochemistry & Molecular Biology
Debasis Das, Lingzhi Xie, Jingbing Wang, Dandan Qiao, Jian Hong
Summary: A series of new pyrazolo[3,4-d]pyrimidine derivatives were synthesized and evaluated for their anti-leukemia activity. All the compounds exhibited good in vitro anti-proliferative activities, with some being more potent than the BTK inhibitor ibrutinib. Promising compounds (IIc, IIk, and III) showed low IC50 values against multiple leukemia cell lines.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Debasis Das, Jingbing Wang, Jian Hong
Summary: This review summarizes the discovery and development of next-generation BTK inhibitors, especially targeting the BTK C481S mutation, and their applications in the treatment of lymphomas and autoimmune diseases.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Organic
Swapan Kumar Biswas, Debasis Das
Summary: This review article compiles the synthesis methods of pyrano[2,3-c]pyrazole derivatives and highlights their applications in medicinal chemistry.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Debasis Das, Dandan Qiao, Zhonghe Liu, Lingzhi Xie, Yong Li, Jingbing Wang, Jianhe Jia, Yuxi Cao, Jian Hong
Summary: A series of selective EP4 antagonists were identified, and compound 36 was discovered as a potent inhibitor. In vivo efficacy studies showed that compound 36 inhibited tumor growth and a combination with capecitabine significantly suppressed tumor growth in mouse models.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
