Adenine as aminocatalyst for green synthesis of diastereoselective Mannich products in aqueous medium

The three-component organocatalysed Mannich type reaction is carried out in a green co-solvent of ethanol and water at room temperature using adenine as catalyst and hydrogen peroxide as additive. The Mannich products are obtained in considerably good diastereoselectivity depending on the effects of substituents on aniline. (C) 2009 Elsevier Ltd. All rights reserved.