Novel Petasis boronic acid reactions with indoles: synthesis of indol-3-yl-aryl-acetic acids

Indoles call serve as Substrates for the Petasis boronic acid-Mannich reaction, providing a practical synthetic route for C-C bond formation in alpha-(N-substituted indole)carboxylic acids. The scope and limitations of this method have been examined. (C) 2008 Published by Elsevier Ltd.