期刊
TETRAHEDRON LETTERS
卷 49, 期 19, 页码 3075-3077出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.03.051
关键词
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The Michael addition of malonates to alpha,beta-unsaturated aldehydes catalyzed by O-TMS protected diphenylprolinols and acetic acid in water occurs at 0 degrees C to rt. In most cases, the reaction runs to completion in less than 24 h. A wide range of aldehydes including beta-aryl, beta-alkyl and beta-alkenyl acroleins are found to be compatible with these conditions, providing the corresponding adducts in good yields and with good to excellent enantioselectivities. (C) 2008 Elsevier Ltd. All rights reserved.
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