Facile synthesis of α-iodo carbonyl compounds and α-iodo dimethyl ketals using molecular iodine and trimethylorthoformate

A novel and direct method for the synthesis of alpha-iodo ketones and alpha-iodo dimethyl ketals from acetophenones using iodine and trimethylorthoformate under neutral conditions is described herein. (C) 2008 Elsevier Ltd. All rights reserved.