Catalytic enantioselective allylation of aldehydes using β-amido functionalized allylstannanes with chiral In(OTf)3/i-Pr-pybox complexes

The enantioselective allylation of aldehydes using a variety of beta-amido functionalized allyltributylstannanes proceeded smoothly with good to high yields and enantioselectivities in the presence of 10 mol % of a chiral catalytic complex prepared from In(OTf)(3) and 2,6-bis[(S)-4-isopropyloxazolin-2-yl]pyridine {(S)-i-Pr-pybox}, providing the corresponding chiral gamma-hydroxy amides. (C) 2008 Elsevier Ltd. All rights reserved.