期刊
TETRAHEDRON
卷 70, 期 13, 页码 2272-2279出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.02.011
关键词
Coupling reactions; Suzuki-Miyaura reaction; Palladium catalyst; Density functional theory; Computational studies; Interactive free energy relationship; Multiple-substituent effects
资金
- CNRS
- Ministere de l'Education Nationale
Concerning the Suzuki-Miyaura coupling reaction, we report detailed theoretical study of thermodynamic data (at the B3PW91/LANL2DZ level with polarization functions added and including dispersion force corrections) concerning each step of the catalytic cycle. In each case, we have observed a Hammett plotting of delta E or delta G versus sigma(p) of substituent of various reagents, which accounts for multiple-substituent effects. Therefore, these calculations predict the influence of the electron-donor/electron-acceptor character of each substituents on the thermodynamic requirements for reaction. Our major conclusion is that the transmetalation between a palladium hydroxo complex and an arylboronic acid is preferable to the transmetalation with a palladium bromo complex. Moreover, the alkaline hydrolysis of palladium bromo complex appears as a strong exothermic reaction. Concerning the reductive elimination step alternative processes have been investigated. The overall process giving rise to biphenyls appears as a very strong exothermic reaction (similar to-110 kcal/mol in ideal gas; similar to-95 kcal/mol using water as solvent). (c) 2014 Elsevier Ltd. All rights reserved.
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