期刊
TETRAHEDRON
卷 69, 期 22, 页码 4479-4487出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.02.080
关键词
Cyclopropane; Palladium catalysis; C-H functionalization; Benzoazepines; Silver
资金
- Universite de Montreal
- Natural Science and Engineering Council of Canada (NSERC)
- Centre for Green Chemistry and Catalysis
- Canada Research Chair Program
- Canada Foundation for Innovation
- NSERC
A variety of difficult to obtain benzo[c]azepine-1-ones are synthesized via a novel palladium-catalyzed, silver-promoted intramolecular cyclization of cyclopropyl benzamides. This biologically important class of molecules is prepared in an efficient and high-yielding manner from easily accessible starting materials. Both aryl bromides and iodides are effective substrates for the transformation. Mechanistic studies indicate that the reaction proceeds through a cyclopropyl C(sp(3))-H cleavage step, followed by ring-opening, deprotonation, and reductive elimination. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据