期刊
TETRAHEDRON
卷 69, 期 22, 页码 4459-4465出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.02.092
关键词
Cobalt catalysis; C-H bond functionalization; Aldimine; Alkyne; Carbocycles
资金
- Singapore National Research Foundation [NRF-RF-2009-05]
- Nanyang Technological University
- JST, CREST
An ortho-alkenylation reaction of an aromatic aldimine with an internal alkyne is efficiently promoted by a cobalt catalyst generated from CoBr2, triarylphosphine, and (PrMgBr)-Pr-i. The reaction takes place under mild room-temperature conditions to afford, upon acidic hydrolysis, a variety of ortho-alkenylated aromatic aldehydes in moderate to excellent yields. The neighboring formyl and alkenyl groups in the product can be utilized as synthetic handles for the facile construction of indene and naphthalene carbocycles. (C) 2013 Elsevier Ltd. All rights reserved.
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