期刊
TETRAHEDRON
卷 69, 期 1, 页码 320-326出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.10.033
关键词
Acylation; Palladium catalysis; 2-Arylbenzoxazole; C-H activation
资金
- National Natural Science Foundation of China [21172200, 21102134]
- Innovation Fund for Outstanding Scholar of Henan Province [621001100]
An efficient and facile catalytic protocol for benzoxazole-directed ortho-acylation of 2-arylbenzoxazoles has been described using aldehydes as the easily accessible acyl source. This catalytic system was performed in the presence of tert-butyl hydroperoxide (TBHP) as the oxidant in chlorobenzene, affording the acylated 2-arylbenzoxazoles in moderate to good yields. The acylation exhibited high regioselectivity for the substrates containing a meta-substituent in the benzene ring and typically occurred at the less sterically hindered ortho-C-H bond of the directing group. (C) 2012 Elsevier Ltd. All rights reserved.
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