期刊
TETRAHEDRON
卷 69, 期 2, 页码 627-635出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.11.012
关键词
Lithium tert-butoxide; Sterically hindered Claisen condensation; 3-Substituted 4-aryl-2,4-diketoesters; Knorr reaction; 4-Substituted 1,5-diaryl-1H-pyrazole-3-carboxylates
资金
- National Natural Science Foundation of China [21176074]
concise 'one-pot' synthesis of a variety of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates has been developed in moderate to good yields with excellent regioselectivity. Less cost lithium tert-butoxide has been identified as a base for sterically hindered Claisen condensation to efficiently generate the labile 3-substituted 4-aryl-2,4-diketoesters. Furthermore, extensive studies lead to a 'one-pot' process by combination of the Claisen condensation and the Knorr reaction for the synthesis of highly valuable 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates. (c) 2012 Elsevier Ltd. All rights reserved.
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