期刊
TETRAHEDRON
卷 68, 期 45, 页码 9267-9271出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.08.066
关键词
Wickerol; Anti-influenza virus; Diterpene; Trichoderma atroviride
Wickerols A and B were produced by a fungus, Trichoderma atroviride FKI-3849. Wickerol A showed potent anti-influenza virus activity against strain A/PR/8/34 (H1N1), whereas wickerol B exhibited weaker impact. The anti-influenza virus spectrum between wickerols A and B was different. The cyclization mechanism of the wickerol carbon-skeleton was investigated by incorporation of C-13-labeled acetate. A pathway through the verticillyl cation was predicted. (C) 2012 Elsevier Ltd. All rights reserved.
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