期刊
TETRAHEDRON
卷 68, 期 10, 页码 2414-2420出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.01.008
关键词
N-Heterocyclic carbene; Palladium complex; Amination reaction; Aryl chloride; Synthetic method
资金
- Opening Foundation of Zhejiang Provincial Top Key Discipline [100061200123]
- Science and Technology Department of Zhejiang Province [2011R424043]
We report herein a well-defined NHC-Pd(II)-Im(NHC=N-heterocyclic carbene; Im=1-methylimidazole) complex catalyzed C-N coupling of primary amines with aryl chlorides. Under the optimal reaction conditions, a variety of primary amines can be coupled with aryl chlorides to give the amination products in good to high yields within 4 h. It is worthy of noting here that the NHC-Pd(II)-Im complex showed especially high catalytic activity toward challenging sterically hindered substrates including both of aryl amines and aryl chlorides. In addition, alkyl amines were also proved to be suitable reaction partners to give the corresponding amination products in good to high yields. (C) 2012 Elsevier Ltd. All rights reserved.
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