期刊
TETRAHEDRON
卷 68, 期 37, 页码 7613-7618出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.06.040
关键词
Kinetic resolution; Diarylmethanols; Biotransformation; Candida antarctica lipase B; Enzymatic resolution
资金
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
An enzymatic kinetic resolution of diarylmethanols via acylation has been developed. This was achieved by the use of a mutated variant of CALB that accepts larger substrates compared to the wild type. By the use of diarylmethanols with two differently sized aryl groups, enantioselective transformations were achieved. A larger size-difference led to a higher enantioselectivity. In addition, substrates with electronically different aryl groups, such as phenyl and pyridyl, also gave an enantioselective reaction. The highest E value was observed with a substrate where steric and electronic effects were combined. (C) 2012 Elsevier Ltd. All rights reserved.
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