期刊
TETRAHEDRON
卷 68, 期 29, 页码 5908-5911出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.04.096
关键词
Chiral sulfinylphosphine; Chalcones; 1,4-Addition
资金
- NSFC [21072186, 20872139]
- West Light Foundation of CAS
- Chengdu Institute of Biology of CAS [Y0B1051100]
- Major State Basic Research Development Program (973 program) [2010CB833300]
A general method to obtain enantioenriched 1,3,3-triarylpropan-1-ones bearing a diarylmethine stereocenter was developed using Rh/chiral sulfinylphosphine catalyzed 1,4-addition of arylboronic acids to chalcones. The catalysis progressed smoothly in the presence of 2 mol % catalyst formed in situ from [Rh(C2H4)(2)Cl](2) and chiral tert-butanesulfinylphosphine and gave the adducts with up to 99% yield and 98% ee. (C) 2012 Elsevier Ltd. All rights reserved.
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