Article
Chemistry, Multidisciplinary
Xiaoxi Lin, Elvira Haimov, Boris Redko, Arkadi Vigalok
Summary: In this study, bulky bidentate (LPtF)-F-IV(Aryl) complexes with a 2-[bis(adamant-1-yl)phosphino]phenoxide ligand (L) demonstrated excellent reactivity and selectivity in the arylation of X-H (X=S, N) bonds of amino acid residues in unprotected peptides under mild conditions. The stepwise addition of these complexes allowed convenient introduction of different aromatic groups and further arylation of N-H bonds in peptides, resulting in peptides bearing multiple aromatic groups.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Avinash Dhamija, Dolly Chandel, Sankar Prasad Rath
Summary: Here, we demonstrate the chiral guest-induced contraction, extension, and twisting motions in a flexible and nano-sized achiral trizinc(ii)porphyrin trimer host. The formation of 1:1, 1:2, and 1:4 host-guest supramolecular complexes leads to the induction, inversion, and amplification, as well as reduction, of porphyrin CD responses in a single molecular framework. The opposite CD signs observed in R and S substrates suggest that chirality is solely determined by the stereographic projection of the chiral center. Additionally, the trisignate CD signals generated by long-range electronic communications between the three porphyrin rings provide further insights into molecular structures.
Article
Chemistry, Multidisciplinary
Manas Kumar Bera, Yoshikazu Ninomiya, Masayoshi Higuchi
Summary: The stepwise introduction of three different transition metals into a metallo-supramolecular polymer has successfully led to the synthesis of a polymer with quad-color electrochromic properties. This synthetic method can be extended to fabricate other MSPs with different compositions, exhibiting a broad optical and electrochemical window.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Engineering, Biomedical
Yihalem Abebe Alemayehu, Fasih Bintang Ilhami, Abere Habtamu Manayia, Chih-Chia Cheng
Summary: This study successfully designed and synthesized a new mercury-based supramolecular polymer with multifunctional properties, exhibiting selective cytotoxic effects on cancer cells without harming normal cells. The discovery of this "cytotoxicity-concealing" supramolecular system provides a promising strategy to enhance the safety and efficacy of cancer therapy and bioimaging.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Meng-Yun Liang, Meng-Jie Zhang, Wei Qiu, Yao Xiao, Meng-Jie Ye, Peng Xue, Yue-Jun Kang, Zhi-Jun Sun, Zhigang Xu
Summary: The study developed a cascaded pH-activated supramolecular nanoprodrug (PDNP) that can effectively induce pyroptosis and enhance immune response through stepwise size shrinkage, combining with anti-PD-1 antibody to amplify tumor suppression.
Article
Green & Sustainable Science & Technology
Xiaogui Zheng, Guohe Huang, Lirong Liu, Xiaoyue Zhang, Chen Lu
Summary: With the rapid development of China's urbanization and industrialization, industrial waste gas emissions have caused severe air pollution. A stepwise clustered industrial waste gas emission management model has been developed to support the formulation of mitigation policies. A case study in Chongqing Municipality shows that the emissions of sulfur dioxide are higher than those of fume and dust, indicating a greater focus on managing fume and dust emissions. Additionally, urban households in Chongqing contribute more to indirect industrial waste gas emissions compared to rural households.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Engineering, Biomedical
Yekui Zhou, Yuanwei Zhang, Wenhai Lin, Samuel J. Kesseli, Ling Huang, Yang Zhao, Xikuang Yao, Kai Huang, Gang Han
Summary: This study reports the first wavelength-selective sequential photolysis from single gold nanoparticles, demonstrating their ability to sequentially release multiple payloads in living cells. By rational design of diverse photocleavable linkers, this system can potentially be extended to sequential release of various types of payloads. The work provides a new tool for better orderly controlling cellular events that require high spatiotemporal precision.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Analytical
Huiqian Zhou, Wenbo Guo, Shian Wang, Tingting Hao, Zhaoliang Wang, Yufang Hu, Sui Wang, Jianjun Xie, Xiaohua Jiang, Zhiyong Guo
Summary: An electrochemical aptasensor has been developed for ultrasensitive detection of Staphylococcus aureus (SA) based on stepwise signal amplification. The sensor exhibits good detection performance and wide applicability to other pathogens.
Article
Chemistry, Multidisciplinary
Yan Liu, Shou-Heng Liao, Wen-Tao Dai, Qixia Bai, Shuai Lu, Heng Wang, Xiaopeng Li, Zhe Zhang, Pingshan Wang, Wei Lu, Qi Zhang
Summary: Construction of supramolecular structures with internal functionalities is a promising approach to build enzyme-like cavities. The endo-functionalized [Pd12L24] and [Pd2L4] coordination cages represent successful systems in this regard. We provide a solution for the controlled endo-functionalization of [Pd2L4] cages through the formation of heteroleptic [Pd-2(L-A)(2)(L-B)-(L-C)] cages. This strategy allows for the selective introduction of different functional groups and provides a new solution for the controlled endo-functionalization of supramolecular cavities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jin-Ho Bae, Hong-Sik Kim, Gijeong Kim, Ji-Joon Song, Hak-Sung Kim
Summary: The research presents a simple bottom-up approach to programmably assemble proteins into supramolecular structures with tunable size and valency. The protein dendrimers exhibit a doubling of valency at the periphery after each generation, allowing for tunable valency and easy functionalization, showing potential applications in targeted delivery and cellular cytotoxicity.
Article
Chemistry, Multidisciplinary
Yingguo Li, Lei Jia, Xianhui Tang, Jinqiao Dong, Yong Cui, Yan Liu
Summary: The development of artificial ion channels is of critical importance for both understanding natural processes and various applications. In this study, we report the self-assembly of a distinct type of four-membered metallacycles with tunable pore microenvironments capable of selectively transporting anions. Our findings reveal the dependence of transport abilities of self-assembled complexes on their pore microenvironments.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Review
Biochemistry & Molecular Biology
Na-Oh Yunn, Junhong Kim, Sung Ho Ryu, Yunje Cho
Summary: In this review, the authors discuss the structural and functional features of the insulin receptor (IR) complexed with various ligands. They propose a model to explain the sequential activation mechanism and provide insights into the design of selective agonists and their clinical implications.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Environmental Sciences
P. P. Wang, G. H. Hung, Y. P. Li
Summary: This study utilizes input-output analysis, stepwise cluster analysis, and factorial analysis to explore the complex water-carbon nexus in China. The findings show significant differences in water-carbon characteristics between the supply and demand sides, and highlight the varying impacts of supply-side policies on different sectors. Allocation-oriented policies are generally more effective in balancing water-carbon pressures and economic development. The study emphasizes the importance of considering the effects of multiple sectors and their interactions, and suggests specific policy combinations for different sectors.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Peng-Fei Cui, Xin-Ran Liu, Yue-Jian Lin, Zhen-Hua Li, Guo-Xin Jin
Summary: This study reports the rational design of a metallacage with carborane functionality and cooperative dihydrogen binding sites for the highly selective capture of cyclohexane molecules, which could potentially have exciting future applications in supramolecular chemistry for the selective adsorption and separation of alkane molecules.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Analytical
Si-Yuan Wang, Yi-Chen Du, Dong-Xia Wang, Jia-Yi Ma, An-Na Tang, De-Ming Kong
Summary: CRISPR/Cas proteins are powerful gene-editing tools and also show great promise in biosensing applications. Various nucleic acid-based signal amplification techniques can greatly improve detection sensitivity and specificity, extend the detectable target range, and enable diverse signal output modes in CRISPR/Cas-based biosensors.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Qingsong Liu, Man Zhang, Ye Fu, Shen Shen, Liangliang Zhu
Summary: In this study, a new family of benzothiazole-enolate-based organoboron luminophores (HN1-4) with efficient dual-phase emission was constructed. HN4 exhibited one of the highest quantum yields among similar compounds. The intense emission in the solid state was attributed to the twisted core structure constructed by the boronic coordination of two penta-fluorobenzene in HN4. Additionally, HN4 showed a unique response to mechanical force accompanied by a reversible change of the quantum yield.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Chen-Yu Shi, Qi Zhang, Bang-Sen Wang, Dan-Dan He, He Tian, Da-Hui Qu
Summary: Controlling dynamic molecular self-assembly offers solutions for rational material design. In this study, the combination of disulfide-mediated ring-opening polymerization and H-bonding self-assembly resulted in the assembly of small molecules into layered ionic networks with tunable architectural properties and controllable functions as ion-transport membranes. The resulting membranes exhibited high efficiency in ion transportation due to the formation of interlayer water channels.
Article
Chemistry, Multidisciplinary
Guogang Liu, Yujian Liu, Chengxi Zhao, Yan Li, Zhaohui Wang, He Tian
Summary: In this study, a molecular carbon C-204 featuring 12-fold [5]helicenes around four cores was successfully constructed, and one pair of enantiomers with D-3 symmetry was obtained. The results suggest that choosing PDIs as building blocks can realize the stereoselectivity and chirality of molecular carbons.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Chen-Yu Shi, Dan-Dan He, Bang-Sen Wang, Qi Zhang, He Tian, Da-Hui Qu
Summary: This study reports a supramolecular poly(disulfides) network with tunable clusteroluminescence, which exhibits mechanical adaptivity and robustness due to the reticular H-bonds. Efficient clusteroluminescence and phosphorescence at 77 K are achieved through slow backbone disulfide exchange and fast side-chain metal coordination, enabling orthogonally tunable luminescence. Further exploration on reprocessability and chemical closed-loop recycling of dynamic networks is feasible for sustainable materials. The synergistic strategy of dynamic chemistry provides a novel pathway and potential opportunities for smart emissive materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyan Xu, Man Zhang, Zhongyu Li, Danfeng Ye, Lizhen Gou, Qi Zou, Liangliang Zhu
Summary: Ligands that can perform photoexcitation-induced aggregation were synthesized and modified onto gold nanoparticles, resulting in highly efficient light-induced self-assembly properties and high-contrast color fading in tens of seconds.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Fan Yang, Bingbing Yue, Liangliang Zhu
Summary: Dynamically controlling supramolecular chirality is crucial for the development of functional chiral materials and their specific function implementation. Light, as an external energy input, provides a remote and accurate means to modulate chiral assemblies. Different methods, such as photochemically reactive units and photo-induced directionally rotating molecular motors, as well as circularly polarized light, have been explored to drive chiral transfer or amplification and induce supramolecular chirality. However, there is a lack of systematic review on this topic. This review summarizes recent studies in the constructions and applications of light-responsive chiral assembled systems, aiming to provide better knowledge for the development of multifunctional chiral nanomaterials.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ruyi Zhang, Liangliang Zhu, Bingbing Yue
Summary: Lanthanide metal-organic frameworks (Ln-MOFs) are important components of luminescent MOFs, possessing characteristics such as good porosity, topological diversity, high surface area, and highly adjustable structure. Ln-MOFs have significant applications in chemical and biological sensors, optical information devices, and catalysis. However, there is a lack of systematic reviews on the various applications of Ln-MOFs. This paper summarizes the latest progress in Ln-MOFs applications, discusses the design mechanism, and provides prospects for potential issues in current research.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Xuejuan Wang, Guofeng Liu, Kuo Fu, Xuping Li, Mengting Yao, Qinghua Lu, Liangliang Zhu, Xiang Ma
Summary: In this study, nanocomposites based on the self-assembly strategy of bovine serum albumin (BSA) and Au(I)-complex were designed and synthesized for Ex-De fluorescence and phosphorescence emission. The nanocomposites showed excellent biocompatibility, water solubility, and color-tunable emission, making them suitable for cell imaging and pressure-responsive luminescence.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shen Shen, Glib V. Baryshnikov, Qishan Xie, Bin Wu, Meng Lv, Hao Sun, Zhongyu Li, Hans agren, Jinquan Chen, Liangliang Zhu
Summary: This research develops a host-guest energy transfer relay strategy to improve the phosphorescence lifetime of multi-twisted luminophores, achieving persistent room-temperature phosphorescence (pRTP) that is visible to the naked eye. Additionally, photoexcitation-induced molecular rearrangement is used to further prolong the phosphorescence lifetime. This work is significant in advancing our understanding of molecular photophysical mechanisms and guiding the study of molecular systems that are difficult to achieve pRTP.
Review
Chemistry, Multidisciplinary
Xiaoyong Jia, Liangliang Zhu
Summary: Photodriven self-assembly is a crucial strategy to regulate the molecular orderliness and structure. While traditional photochemical self-assembly has disadvantages, physical processes based on photoexcitation can fully utilize photons to avoid drawbacks. These processes drive molecular movement and aggregation, promoting the assembly of materials. The exploration of photoexcitation-induced assembly can lead to the development of unprecedented optoelectronic materials.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Hao Sun, Lulu Zhou, Ruoqu Gong, Man Zhang, Shen Shen, Mouwei Liu, Cisong Wang, Xiaoyan Xu, Zhongyu Li, Jianshuo Cheng, Wenbo Chen, Liangliang Zhu
Summary: We developed a novel strategy to achieve multiple stimuli-responsive phosphorescent activation on a single carbon-dot system by introducing aromatic carbonyl groups and multiple S atoms. This strategy enables the activation of the phosphorescent property by light, acid, and thermal stimuli, leading to tunable and multistimuli-responsive phosphorescence.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell Biology
Jian Jin, Bo-han Pan, Kang-an Wang, Shao-Shuo Yu, Guo-sheng Wu, He Fang, Bang-hui Zhu, Yu Chen, Liang-liang Zhu, Yan Liu, Zhao-fan Xia, Shi-hui Zhu, Yu Sun
Summary: This study aimed to investigate the mechanism of how a subvacuum environment promotes wound epithelisation without affecting scar hyperplasia by examining changes in cell proliferation, migration, target proteins, calcium influx, cytoskeleton, and membrane fluidity. The results showed that the subvacuum environment promoted cell migration without influencing cell proliferation, leading to increased intracellular calcium concentrations and levels of related proteins. Additionally, the cytoskeleton was depolymerized, pseudopodia were reduced or absent, and membrane fluidity increased. The use of calcium channel blockers weakened or eliminated these changes. Animal experiments confirmed these findings and demonstrated the effectiveness of subvacuum dressings in promoting wound epithelisation.
CELL PROLIFERATION
(2023)
Article
Chemistry, Applied
Danfeng Ye, Zhongyu Li, Xiaoyan Xu, Man Zhang, Mouwei Liu, Qi Zou, Liangliang Zhu
Summary: Proton donating ability is crucial in chemical, physical, and biological processes. However, there is a lack of suitable models for quantitative visualization. In this study, fluorescent chemoprobes based on ortho-pyridinyl anilines were synthesized, and their fluorescence signal showed a quantitative relationship with intermolecular hydrogen bond strength. This allowed for the quantification of the proton donating ability of external proton donors through competitive hydrogen bond formation.
Review
Engineering, Biomedical
Yulong Shi, Yiran Zhang, Liangliang Zhu, Yuqing Miao, Yueqi Zhu, Bingbing Yue
Summary: Core-shell structured nanocarriers have gained attention in recent years due to their wide applications and intriguing properties. However, systematic reviews on stimulus-responsive core-shell structured nanocarriers are uncommon. This review categorizes core-shell structured nanocarriers based on different drug payload methods, highlights controlled release mechanisms achieved through stimulus-response processes, and addresses multifaceted perspectives on the design of core-shell structured materials as drug carriers.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Hao Sun, Liangliang Zhu
Summary: Organic room temperature phosphorescence (RTP) materials are widely used in various applications, but achieving RTP in water solution remains a challenge. This review summarizes recent cases of aqueous phase organic RTP emission and discusses efficient design strategies and potential applications.
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
