期刊
TETRAHEDRON
卷 68, 期 37, 页码 7685-7690出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.06.032
关键词
Asymmetric catalysis; Hydrogenation; Chiral spiro ligands; beta-Arylenamides; beta-Arylisopropylamines
资金
- National Natural Science Foundation of China
- National Basic Research Program of China [2010CB833300, 2011CB808600]
- '111' project of the Ministry of Education of China [B06005]
A highly enantioselective rhodium-catalyzed hydrogenation of both (Z)- and (E)-beta-arylenamides was developed by using monodentate chiral Spiro phosphite and phosphine ligands, respectively. The hydrogenation reaction provides an efficient access to optically active beta-arylisopropylamines, important building blocks for the synthesis of biologically active compounds. (C) 2012 Elsevier Ltd. All rights reserved.
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