期刊
TETRAHEDRON
卷 68, 期 26, 页码 5185-5192出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.03.109
关键词
Asymmetric hydrogenation; Ruthenium; N-Heterocyclic carbenes; Benzofuran; 2,3-Dihydrobenzofuran
资金
- Deutsche Forschungsgemeinschaft [SFB 858]
- Alfried Krupp Prize for Young University Teachers of the Alfried Krupp von Bohlen und Halbach Foundation
A short and efficient synthesis of ent-corsifuran A by a highly asymmetric hydrogenation of a benzofuran precursor is reported. In addition, the electronic influence of the substituents on the asymmetric hydrogenation of benzofurans is provided. Whereas the hydrogenation of electron-deficient benzofurans was achieved under very mild conditions, the presence of electron-donating groups in the benzofuran required harsher reaction conditions for achieving full conversion to the 2,3-dihydrobenzofuran. (C) 2012 Elsevier Ltd. All rights reserved.
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