期刊
TETRAHEDRON
卷 68, 期 24, 页码 4820-4829出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.03.116
关键词
Kadsura polysperma; Lanostane triterpene acid; Kadpolysperins; Cytotoxicity
资金
- NSFC [30830115, 20902093]
- Science and Technology Program of Yunnan Province [2008GA031]
- Major State Basic Research Development Program of China [2009CB522300]
- Western Doctoral Foundation of Chinese Academy of Sciences
- Reservation-Talent Project of Yunnan Province
Fourteen new lanostane triterpene acids (1-14), and five known analogues (15-19) were isolated from the stems of Kadsura polysperma. Compound 1, with a rearranged tetracyclic skeleton, is an important biogenic precursor of longipedlactone skeleton. Compounds 2-6 are members of 18(13 -> 12)-abeo-lanostane triterpene acids. The structures of new compounds were elucidated by spectroscopic evidence. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. (C) 2012 Elsevier Ltd. All rights reserved.
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