期刊
TETRAHEDRON
卷 68, 期 5, 页码 1376-1383出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.12.045
关键词
Aeruginazole; Cyclic peptide; Natural product; Cyanobacteria; Microcystis
资金
- Israel Science Foundation [037/02, 776/06]
Three related cyclic peptides, aeruginazole DA1497 (1), aeruginazole DA1304 (2), and aeruginazole DAl274 (3), were isolated from the freshwater cyanobacteria, Microcystis aeruginosa, bloom material collected on October 2007 from the Dalton water-reservoir in Northern Israel. Aeruginazoles DA1304 (2), DA1338 (4), and DA1372 (5) were isolated as an inseparable mixture from a bloom material of M. aeruginosa collected from the same water-reservoir on August 2000. Their structures were elucidated using a combination of various spectroscopic techniques, mainly NMR and MS, while the absolute stereochemistry of the chiral centers were determined by Marfey's method. Aeruginazoles 1-3 were tested in various bioassays (antibacterial, cytotoxicity, and protease inhibition). Aeruginazole DA1497 (1) showed a mild antimicrobial activity against Staphylococcus aureus, but was inactive like the rest of the compounds in all other bioassays. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据