Article
Nursing
Sandra Schmidt Bunkers
Summary: The author explores the significance of wandering and wondering from various disciplines, presenting a fictional story to highlight the creative power of imagination involved in these processes.
NURSING SCIENCE QUARTERLY
(2022)
Article
Gastroenterology & Hepatology
Henrik M. Roager, Catherine Stanton, Lindsay J. Hall
Summary: The development of the infant gut microbiome is crucial for the microbiome ecology, function, and host health. Technological advancements now allow for better profiling of metabolites in the infant gut, providing insights into the roles of microbial-derived metabolites in shaping the microbiome community and influencing host-microbial interactions during early life. This review summarizes the current knowledge on the development of the infant gut microbiota and metabolism within the first year of life, emphasizing the importance of microbial metabolites in enhancing our understanding of early life interactions.
Article
Health Care Sciences & Services
I-Wen Wu, Tsung-Hsien Tsai, Chi-Jen Lo, Yi-Ju Chou, Chi-Hsiao Yeh, Yun-Hsuan Chan, Jun-Hong Chen, Paul Wei-Che Hsu, Heng-Chih Pan, Heng-Jung Hsu, Chun-Yu Chen, Chin-Chan Lee, Yu-Chiau Shyu, Chih-Lang Lin, Mei-Ling Cheng, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Summary: AI-assisted models using machine learning algorithms were developed to identify biomarker signatures for diabetic kidney disease. The study reveals molecular mechanisms underlying the interaction between diabetes and chronic kidney disease, improving precision in diagnosing renal impairment.
NPJ DIGITAL MEDICINE
(2022)
Article
Chemistry, Applied
Derio Brioschi Junior, Rogerio Carvalho Guarconi, Marliane de Cassia Soares da Silva, Tomas Gomes Reis Veloso, Maria Catarina Megumi Kasuya, Emanuele Catarina da Silva Oliveira, Jose Maria Rodrigues da Luz, Tais Rizzo Moreira, Danieli Grancieri Debona, Lucas Louzada Pereira
Summary: This study introduced a new processing method for coffee using carbonic maceration, which showed a significant functional relationship between global score and fermentation temperature of 38 degrees Celsius for 96 hours. Bacterial diversity had a positive correlation with sensory characteristics, and compounds like trigonelline and formic acid contributed to the sensory quality of coffee beverage. This data provides insights into the microbiological action on the sensory quality of coffee beverage.
Review
Pharmacology & Pharmacy
Zhiyou Yang, Jiahang Deng, Mingxin Liu, Chuantong He, Xinyue Feng, Shucheng Liu, Shuai Wei
Summary: Panax quinquefolius L. has gained global attention for its pharmacological properties on type 2 diabetes, cancers, central nervous system, and cardiovascular diseases. Ginsenosides, the active phytochemicals of P. quinquefolius, have diverse structures and limited bioavailability, hindering the development of medicines. This review provides an overview of the structures of minor ginsenosides in P. quinquefolius and summarizes the recent pharmacological studies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Microbiology
Qingru Jiang, Tian Li, Wei Chen, Yingfang Huo, Xiangyu Mou, Wenjing Zhao
Summary: The microbiota, especially the maternal-associated microbial metabolites, play a crucial role in individuals' early and long-term health. However, the relationship between maternal-associated microbial metabolites and offspring diseases is still poorly understood. This review aims to summarize current knowledge on these metabolites and their links to the development of various offspring diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
William L. King, Caylon F. Yates, Lily Cao, Sean O'Rourke-Ibach, Suzanne M. Fleishman, Sarah C. Richards, Michela Centinari, Benjamin D. Hafner, Marc Goebel, Taryn Bauerle, Young-Mo Kim, Carrie D. Nicora, Christopher R. Anderton, David M. Eissenstat, Terrence H. Bell
Summary: Traditionally, fine roots were grouped without considering their heterogeneity in physiology, morphology, and functionality among different orders. This study examined the differences in microbial composition, potential microbial functions, and root metabolome between absorptive and transportive fine roots of four temperate tree species. The results showed that the bacterial community, potential microbial functions, and root metabolome were influenced by root functional type.
PLANT CELL AND ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Xiaoxuan Wu, Yu Yang, Huiming Zhang
Summary: Medicinal plants produce secondary metabolites that are influenced by environmental factors and plant-associated microbiomes. Recent studies have shown that exploiting microbial capacities can enhance the production of pharmacological metabolites in medicinal plants. This review summarizes these studies and discusses the potential of microbial applications for metabolic fortification in medicinal plants.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Ecology
Amrita Chakraborty, Dagmar Zadrapova, Jakub Dvorak, Zuzana Faltinova, Petr Zacek, Tomas Cajthaml, Jiri Korecky, Amit Roy
Summary: Anthropogenic disturbances and climate change have an impact on abiotic and biotic environmental factors in forest ecosystems. The present study focuses on the influence of long-term precipitation variation and soil texture on soil microbial assemblage and function in Norway spruce stands. Results showed that higher precipitation correlated positively with total organic carbon (TOC), total nitrogen (TN), extracellular enzyme activities (EEAs), and phospholipid fatty acids (PLFA) content, while microbial diversity showed an opposite trend. The study provides field data for modeling the impact of long-term precipitation and soil texture on soil microbial assemblage and function.
FRONTIERS IN FORESTS AND GLOBAL CHANGE
(2023)
Article
Environmental Sciences
Shivananda Behera, Monika Priyadarshanee, Vandana, Surajit Das
Summary: The rising plastic pollution has negative impacts on the environment due to the non-biodegradable nature of petroleum-based plastics. Polyhydroxyalkanoates (PHAs) offer a sustainable and eco-friendly alternative as they can be synthesized using various microorganisms and possess enhanced biodegradability and other useful properties. This review provides an overview of the synthesis mechanism, properties, and applications of microbially synthesized PHAs, as well as discussing the classification, detection techniques, genetic regulation, and industrial production of these biopolymers.
Article
Gastroenterology & Hepatology
Yali Liu, Harry Cheuk-Hay Lau, Jun Yu
Summary: Trillions of microbes in the human gastrointestinal tract form an ecological community known as the gut microbiota, which plays a crucial role in dietary digestion and produces various metabolites. However, these microbial metabolites have been found to be correlated with the development of colorectal cancer (CRC) and can also impact the efficacy of cancer treatments. This review discusses the role of metabolites derived from microbes-mediated metabolism of dietary components and their influence on CRC development, as well as their impacts on chemotherapy and immunotherapy. Targeting metabolites may be a promising therapeutic approach for improving patient outcome in CRC.
Review
Physiology
Andrew S. Neish
Summary: It is now known that eukaryotic hosts have evolved mechanisms to monitor and respond to the microbiota in a symbiotic manner, with implications for drug and xenobiotic metabolism. These mechanisms are based on immune processes and gene regulatory networks that detect and respond to microbiota-derived small metabolites.
Review
Biochemical Research Methods
Muhammad Saad Ahmed, Kyle J. Lauersen, Sana Ikram, Chun Li
Summary: This study provides insights into efflux transport proteins as potential solutions for enhancing the export of heterologous metabolites from microbial cell systems, including their mechanistic modes of action, selection of appropriate transporters, and future research directions.
ACS SYNTHETIC BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sanna Lensu, Satu Pekkala
Summary: A physically active lifestyle and exercise are associated with a healthy gut microbiota, benefiting from medium-intensity endurance exercise. However, this connection varies depending on study population and exercise protocol, and improvements induced by exercise may disappear in previously sedentary subjects. Controlling for diet in future longitudinal studies on the gut microbiota and physical performance is essential.
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.