Triterpenoids from the stems of Kadsura ananosma

An extensive study of the triterpenoids produced by the stems of Kadsura ananosma, has led to the isolation of eleven new ones, kadnanolactones A-I (1-4,7-11) and kadnanosic acids A(S) and B (6), and six known analogues. Their structures were elucidated mainly by comprehensive spectroscopic analysis, and DFT computational methods were applied to validate the stereochemistry of an epoxide in compound 7. All triterpenoids were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, PANC-1, and SK-BR-3 human cancer cells. (C) 2010 Elsevier Ltd. All rights reserved.