Review
Engineering, Environmental
Adeyemi S. Adeleye, Jie Xue, Yixin Zhao, Alicia A. Taylor, Jenny E. Zenobio, Yian Sun, Ziwei Han, Omobayo A. Salawu, Yurong Zhu
Summary: Pharmaceuticals and personal care products (PPCPs) are commonly found in wastewater and the environment, primarily entering municipal wastewater systems through human excretion and also from hospitals, PPCPs manufacturers, and agriculture. The most abundant PPCPs in raw wastewater include analgesics, antibiotics, and stimulants. In conventional wastewater treatment plants, most removal of PPCPs occurs during secondary treatment, with an overall removal rate exceeding 90%.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Organic
Graham A. Hudson, Annie R. Hooper, Adam J. DiCaprio, David Sarlah, Douglas A. Mitchell
Summary: The study successfully identified and synthesized a new class of natural products, named pyritides, using a combination of bioinformatics, enzymology, and synthetic methods. These pyritides have a unique structure distinct from thiopeptides, with predicted enzymatic reactions leading to the formation of a trisubstituted pyridine-based macrocycle. The research demonstrates the potential of integrating bioinformatics, enzymology, and synthesis to characterize novel natural product scaffolds with interesting structural features and biological activities.
Article
Chemistry, Multidisciplinary
Cedric Couturier, Sebastian Gross, Alexander von Tesmar, Judith Hoffmann, Selina Deckarm, Anouchka Fievet, Nelly Dubarry, Thomas Taillier, Christoph Poeverlein, Heike Stump, Michael Kurz, Luigi Toti, Sabine Haag Richter, Dietmar Schummer, Philippe Sizun, Michael Hoffmann, Ram Prasad Awal, Nestor Zaburannyi, Kirsten Harmrolfs, Joachim Wink, Emilie Lessoud, Thierry Vermat, Veronique Cazals, Sandra Silve, Armin Bauer, Michael Mourez, Laurent Fraisse, Corinne Leroi-Geissler, Astrid Rey, Stephanie Versluys, Eric Bacque, Rolf Mueller, Stephane Renard
Summary: This article describes the myxobacterial natural product Corramycin isolated from Corallococcus coralloides. Corramycin exhibits anti-Gram-negative activity against Escherichia coli and is taken up via two transporter systems. The biosynthetic gene cluster (BGC) of Corramycin was identified and a biosynthesis model was proposed. The absolute configuration of the molecule was elucidated through bioinformatic analysis and total synthesis. Animal experiments confirmed the antibacterial effect of Corramycin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Prabhakara R. Tharra, Andrey A. Mikhaylov, Jiri Svejkar, Marina Gysin, Sven N. Hobbie, Jakub Svenda
Summary: We report a concise synthesis method for the naturally occurring protein synthesis inhibitor (+)-actinobolin. The complex molecular structure of 1 was assembled using (-)-quinic acid, L-threonine, and L-alanine. Our simplified synthesis route, consisting of 9 steps with 18% overall yield, has practical applications for analog preparation, as shown in this study.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Medicinal
Yueting Deng, Yang Liu, Juan Li, Xiao Wang, Shan He, Xiaojun Yan, Yutong Shi, Weiyan Zhang, Lijian Ding
Summary: Biofilm is a complex microbial consortium with resistance mechanisms to known antibiotics, posing a threat to human health. Marine organisms provide abundant resources for the development of anti-biofilm agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Christian P. Bold, Cindy Klaus, Bernhard Pfeiffer, Jasmine Schurmann, Rafael Lombardi, Daniel Lucena-Agell, J. Fernando Diaz, Karl-Heinz Altmann
Summary: The synthesis of an oxazole-based analog of (-)-zampanolide was studied, with successful construction of (-)-dactylolide analog 22. However, attempts to attach (Z,E)-sorbamide failed, possibly due to the migration of the C(8)-C(9) double bond in the macrocycle. This limitation may affect the utility of zampanolide analogs with aromatic moieties as tetrahydropyran replacements.
Article
Chemistry, Multidisciplinary
Alexander O. Brachmann, Silke I. Probst, Joel Ruethi, Darya Dudko, Helge B. Bode, Joern Piel
Summary: This study identified a cryptic biosynthetic locus encoding an N-acyltransferase and a non-heme diiron desaturase-like enzyme in a bacterium producing labradorin through transposon mutagenesis. Heterologous expression in E. coli demonstrated the ability of both enzymes to produce indolyloxazoles, and stable-isotope feeding experiments provided evidence for an unusual desaturase mechanism generating the oxazole by decarboxylative cyclization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Georg Niggemeyer, Anastasia Knyazeva, Raphael Gasper, Dale Corkery, Pia Bodenbinder, Julian J. Holstein, Sonja Sievers, Yao-Wen Wu, Herbert Waldmann
Summary: Design and synthesis of pseudo-natural products through recombination of natural product fragments enables the discovery of novel biologically relevant chemical matter. In this study, the combination of this principle with macrocycle formation was described, leading to the efficient synthesis of 163 macrocyclic pseudo-natural products. Biological investigation revealed their potent inducers of autophagy-related processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Microbiology
Polpass Arul Jose, Anjisha Maharshi, Bhavanath Jha
Summary: Actinobacteria are recognized as important biosynthetic factories that produce a wide range of secondary metabolites. Recent genomic insights have impacted the exploitation and discovery of new compounds from these metabolically active bacteria, leading to significant progress in the field of drug discovery.
MICROBIOLOGICAL RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Debobrata Paul, Ashis Kundu, Sanu Saha, Rajib Kumar Goswami
Summary: This feature article highlights total synthesis as a reliable tool for confirming the structure of natural products. Despite advances in spectroscopic techniques, structural misassignments of natural products remain common. Recent case studies have shown that chemical synthesis can be used to revise the structures of natural products.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yanan Du, Anyarat Thanapipatsiri, Kenichi Yokoyama
Summary: Nucleoside natural products have diverse biological activities and can be used for various applications, including medicine and agriculture. Previous studies have revealed the biosynthetic mechanisms of these nucleosides, involving early steps classified into two types and downstream tailoring enzymes for structural diversity. By investigating two enzymes representing these types of modifications, it is possible to discover putative nucleoside biosynthetic gene clusters and predict core nucleoside structures, suggesting the potential for future discovery of novel nucleoside natural products.
Review
Biochemical Research Methods
Felix Kaspar, Anett Schallmey
Summary: Enzymes are recognized as valuable tools in synthetic chemistry, enabling transformations that conventional organochemical approaches cannot achieve. Their expanding role in biocatalysis has introduced new opportunities for synthetic strategies and retrosynthetic disconnections. This review highlights recent literature examples to demonstrate the strategic uses of enzymes in natural product synthesis and advocates for their inclusion in the standard repertoire for complex small-molecule synthesis.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Helena H. Chubatsu Nunes, Trinh-Don Nguyen, Thu-Thuy T. Dang
Summary: Many chemical compounds from plants have complex structures and potent bioactivities, but their industrial-scale production and development are hindered by their structural complexity. This article highlights recent discoveries of plant-derived biocatalysts and their potential for sustainable and greener chemical production.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Michael J. Zeiler, Gina M. Connors, Greg M. Durling, Allen G. Oliver, Lewis Marquez, Roberta J. Melander, Cassandra L. Quave, Christian Melander
Summary: Antibiotic resistance has become a serious problem, requiring new approaches to combat infections caused by resistant bacteria. One such approach is the development of small molecules called adjuvants, which enhance the activity of conventional antibiotics. This study discovered a natural product called (-)-LZ-2112 that synergizes with oxacillin to fight against methicillin-resistant Staphylococcus aureus. Further research identified key structural elements of (-)-LZ-2112 and suggested the possibility of simplifying its structure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Evan P. Vanable, Laurel G. Habgood, James D. Patrone
Summary: Natural products, with their complex structures, diversity, and biological activity, have inspired chemists and driven technological advancements. The field of natural product synthesis continuously evolves, improving selectivity, yield, scalability, and more. One interesting and unique technique is the use of chemoenzymatic reactions in the synthesis of natural products.
Article
Materials Science, Multidisciplinary
Terry Ching, Yi-Chin Toh, Michinao Hashimoto
ADVANCED ENGINEERING MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Rahul Karyappa, Terry Ching, Michinao Hashimoto
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biochemical Research Methods
Azusa Shimizu, Wei Huang Goh, Shun Itai, Rahul Karyappa, Michinao Hashimoto, Hiroaki Onoe
Article
Chemistry, Analytical
Sindhu Vijayan, Pravien Parthiban, Michinao Hashimoto
Summary: PolyJet (TM) 3D printers are commonly used for fabricating microfluidic molds, but the printed microstructures exhibit deviations in both lateral and vertical dimensions. The spreading of resin leads to larger width than designed, affecting the reproduction of intended heights in narrow-designed microstructures. Mathematical models developed in this study can accurately predict the dimensional deviations and may be useful for designing and fabricating microstructures using PolyJet printers.
Article
Chemistry, Analytical
James S. Ng, Michinao Hashimoto
Summary: This paper introduces a method of utilizing FDM printing to fabricate paper-based analytical devices with three-dimensional features, using two types of thermoplastics to overcome limitations related to organic solvents in traditional PADs. The study validated the capability and potential applications of 3D-PADs in holding increased amounts of liquid samples and demonstrated colorimetric assays for organic solvent-based reactions.
Article
Engineering, Biomedical
Justin Jia Yao Tan, Cheng Pau Lee, Michinao Hashimoto
INTERNATIONAL JOURNAL OF BIOPRINTING
(2020)
Article
Chemistry, Multidisciplinary
Cheng Pau Lee, Rahul Karyappa, Michinao Hashimoto
Article
Chemistry, Multidisciplinary
James S. Ng, Michinao Hashimoto
Article
Biochemical Research Methods
Azusa Shimizu, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miura, Hiroaki Onoe
Proceedings Paper
Engineering, Electrical & Electronic
Azusa Shimizu, Wei Huang Goh, Michinao Hashimoto, Shigenori Miura, Hiroaki Onoe
2019 20TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS & EUROSENSORS XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)
(2019)
Article
Chemistry, Multidisciplinary
Rahul Karyappa, Akihiro Ohno, Michinao Hashimoto
MATERIALS HORIZONS
(2019)
Article
Computer Science, Information Systems
Elizaveta Motovilova, Srikumar Sandeep, Michinao Hashimoto, Shao Ying Huang
Article
Biochemical Research Methods
Louis Jun Ye Ong, Terry Ching, Lor Huai Chong, Seep Arora, Huan Li, Michinao Hashimoto, Ramanuj DasGupta, Po Ki Yuen, Yi-Chin Toh
Article
Chemistry, Physical
Pravien Parthiban, Patrick S. Doyle, Michinao Hashimoto
Article
Chemistry, Multidisciplinary
Sindhu Vijayan, Michinao Hashimoto
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
